Lorimer, G (1992) Role of accessory proteins in protein folding. Curr. Opin. struct. Biol. 2: pp. 26-34Lorimer, G.H. 1992 Role of accessory proteins in protein folding. Curr. Opinion Struct. Biol. 2 , 26–34.Lorimer, G. L. ( 1992 ) Role of accessory proteins in protein folding...
(Fig.2d). Glutamate should also fulfill the role of binding the N-terminal free amine group of ligand proteins, but would change the shape of the pocket. We examined the impact of glutamate substitution of D654 on the binding specificity of CtNbr1 FW domain (Fig.4c). The pocket with D...
Weathers et al. used hydrophilicity and hydrophobicity as the reduction rule for functional classification prediction of intrinsically disordered proteins, and pointed out that hydrophobic amino acids play a central role in stabilizing folded proteins in 2004[36]. In 2006, Melo proposed the ...
The extracellular matrix (ECM) plays a key role in the modulation of cancer cell invasion. In urothelial carcinoma of the bladder (UC) the role of ECM proteins has been widely studied. The mechanisms, which are involved in the development of invasion, progression and generalization, are complex...
C. Protein footprinting by the combined use of reversible and irreversible lysine modifications. Proc. Natl Acad. Sci. USA 91, 11904–11908 (1994). Article CAS PubMed PubMed Central Google Scholar Leitner, A. A review of the role of chemical modification methods in contemporary mass ...
Role of Structural Bioinformatics in Drug Discovery by Computational SNP Analysis:A Proposed Protocol for Analyzing Variation at the Protein Level... David,K,Brown,... - 《Global Heart》 被引量: 0发表: 2017年 Human MicroRNA Targets MicroRNAs (miRNAs) interact with target mRNAs at specific sites...
Genome sequencing projects are producing linear amino acid sequences, but full understanding of the biological role of these proteins will require knowledge of their structure and function. Although experimental structure determination methods are providing high-resolution structure information about a subset...
Proteins that have grossly similar structures are classified as more closely related (Andreevaet al., 2008). This plays an important role in the search and detection of homology. In the SCOP database, the amino acid sequence identity within a protein family must be at leas...
The role of GTPBP10 in H89 maturation Recently, cryo-EM structures of the homologous GTPase ObgE have been solved on the native pre-50S and mature 50S LSU from E. coli39. Structures and biochemical evidence provide mechanistic insight how ObgE aids the organization of the LSU catalytic center...
Structural information on the interactions of proteins with other molecules is plentiful, and for some proteins and protein families, there may be 100s of available structures. It can be very difficult for a scientist who is not trained in structural bio