我们已经与结构基因组学联盟(SGC)合作,为研究临床相关蛋白靶标提供了充分鉴定的新型化学探针。这些探针由SGC开发和鉴定,符合严格的效价、选择性和细胞通透性标准,可以用作临床前靶标验证的必要工具。SGC最初专注于涉及表观遗传控制的蛋白质(包括经过充分研究的靶标,例如含溴结构域的BET家族蛋白质和组蛋白甲基转移酶...
Structural Genomics Research Consortium Structural geology Structural Geology and Basin Analysis structural glass Structural Glazed Facing Tile structural glazing structural glued-laminated timber Structural health monitoring Structural Heart Disease Structural Heart Disease Symposium ...
The Structural Genomics Consortium October 2008 Introducing the SGCToronto, S G COxford, S G CStockholm, S G C
purified proteins out of 95 [6]. Lastly, the Structural Genomics Consortium (SGC, Toronto, Canada) selected 400 distinctP. falciparumtarget genes representing different cellular classes, along with orthologues from four otherPlasmodiumspecies as well asCryptosporidium parvumandToxoplasma gondii[7]. From ...
Davis, T.L., Paramanathan, R., Butler-Cole, C., Finerty Jr., P.J., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC). (2006). Catalytic Domain of Human Calpain 8. PDB: 2NQA. Google Scholar...
As many of the structural genomics centers have ended their first phase of operation, it is a good point to evaluate the scientific impact of this endeavour. The Structural Genomics Consortium (SGC), operating from three centers across the Atlantic, investigates human proteins involved in disease ...
Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA Carrow I. Wells & David H. Drewry Contributions G.S.P. performed and analyzed protein purification, crystallization, and ITC experiments. A.S.S performed and...
Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, UK Simon R. Bushell, Ashley C. W. Pike, Chitra A. Shintre, Annamaria Tessitore, Amy Chu, Qinrui Wang, Leela Shrestha, Shubhashish M. ...
Yantsevich, and SGC members F. MacKenzie and Dr. W. Tempel for excellent technical assistance. The Structural Genomics Consortium is a registered charity (No. 1097737) and receives funds from the Canadian Institutes for Health Research, the Canadian Foundation for Innovation, Genome Canada through ...
Structural Genomics Consortium, Toronto, Ontario, Canada Yong Wei & Yufeng Tong Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada Diana Resetca, Brian Raught & Linda Z. Penn Molecular and Cellular Biology Laboratory, Graduate School of Medical Life Science, Yokohama Ci...