The Psychiatric Genomics Consortium (http://pgc.unc.edu), now in its eighth year, is one of the most innovative experiments in the history of psychiatry. We have unified much of the field to enable rapid progress in elucidating the genetic basis of psychiatric disorders. We have 800+ ...
The PGC Cross-Disorder Workgroup identified several loci that appear to confer risk across autism, ADHD, bipolar disorder, major depressive disorder, and schizophrenia (Cross-Disorder Group of the Psychiatric Genomics Consortium, 2013). Aggregate genome-wide analyses (using SNP-heritability estimates and...
The discovery sample for SCZ PRS estimation included those individuals with European ancestry from the Waive 3 Schizophrenia Meta-analysis [62], which constitutes the SCZ GWAS data most recently uploaded to the Psychiatric Genomics Consortium (PGC) webpage (https://www.med.unc.edu/pgc/download-res...
AcceptedArticlePreview:PublishedaheadofadvanceonlinepublicationNeuropsychopharmacology.neuropsychopharmacologyMethylphenidatemodifiesthemotionofthecircadianclockLamotrigineinmooddisordersandcocainedependenceCorticalglutamateinpostpartumdepressionThePsychiatricGenomicsConsortiumPosttraumaticStressDisorderWorkgroup:Posttraumaticstressdisorderenters...
ADHD = attention-deficit/hyperactivity disorder; ASD = autism spectrum disorder; MDD = major depressive disorder; OCD = obsessive-compulsive disorder; PGC = Psychiatric Genomics Consortium. Please note color figure is available online. Genetic Factors Explaining Stability in Traits or Associations With ...
We obtained data on psychiatric disorders from the Psychiatric Genomics Consortium (https://pgc.unc.edu/about-us/, accessed on 21 April 2023). Data pertaining to depression were acquired from a comprehensive genome-wide meta-analysis encompassing a total of 807,553 individuals of European ancestry...
Post-traumatic stress disorder (PTSD) is a severe and heterogenous psychiatric disorder that was first defined as a mental disorder in 1980. Currently, the Diagnostic and Statistical Manual of Mental Disorders Fifth Edition (DSM-5) and the International Classification of Diseases 11th Edition (ICD-...
The international Psychiatric Genomics Consortium (PGC) is a means to achieve this, sharing both datasets and expertise [59]. International research collaborations have also allowed the leveraging of neuroimaging taking place in different locations through the ENIGMA program [60]. Record linkage All of...
consortium: the Psychiatric Genomics Consortium (PGC). In contrast, only a handful of GWAS of PTSD have appeared in the literature to date. Here we describe the formation of a group dedicated to large-scale study of PTSD genetics: the PGC-PTSD. The PGC-PTSD faces challenges related to the...
PGC: Psychiatric GenomicsConsortium. Full size image Mendelian randomization results for each psychiatric disorder are shown in Table 2. For bipolar disorder, odds ratio of 0.90 (95% CI:0.69; 1.16) and 0.88 (95% CI: 0.62; 1.25) per 1-standard deviation (SD)increment in BMI were obtained ...