(1986). Structural aspects of intermediate filaments. In Cell and Molecular Biol- ogy of the Cytoskeleton (J. W. Shay, Ed.), pp. 41-68. Plenum, New York.Geisler N, Weber K: Structural aspects of intermediate fila- ments. In Shay JW, ed. Cell and Molecular Biology of the Cytoskeleton...
Human loricrin keratoderma, should it also display a permeability barrier abnormality, as does the murine mimic (Suga et al, 2000), would provide a valuable model to test the role of the major protein constituent of the CE in epidermal permeability barrier function. To dissect the pathogenesis,...
Here we focus on the design of novel materials whose properties are encoded by their constituent amino acid sequences. Although we are at the very beginning of the era in which we will be able to precisely specify a material's properties by ‘dialing in’ the proteins we use, there have ...
In the case of \(\alpha =0.5\), the cell architecture may be messy, but the 1st-level hierarchical structure (i.e., the cytoplasm) serves as the major constituent bearing the external force with creep response \({J}_{1} \sim {t}^{0.5}\). By varying the parameters (e.g., \(...
et al. Architecture of the human ndc80-hec1 complex, a critical constituent of the outer kinetochore. J. Biol. Chem. 280, 29088–29095 (2005). 45. Westermann, S., Drubin, D. G. & Barnes, G. Structures and functions of yeast kinetochore complexes. Annu. Rev. Biochem. 76, 563–591...
In fact, the contribution of abundant hippocampal Lewy neurites to dementia was appreciated well before the discovery that α-syn was the primary constituent of Lewy pathology [14]. Presynaptic aggregates of α-syn in the cortex of DLB patients correspond to reduced dendritic spines, suggesting ...
Over the past decade our laboratory has focused on understanding how soluble cytoskeleton-associated proteins interact with membranes and other lipid aggregates. Many protein domains mediating specific cell membrane interactions appear by fluorescence microscopy and other precision techniques to be partially ...
Over the past decade our laboratory has focused on understanding how soluble cytoskeleton-associated proteins interact with membranes and other lipid aggregates. Many protein domains mediating specific cell membrane interactions appear by fluorescence microscopy and other precision techniques to be partially ...
Whereas the major structural components of the two former systems—actin and tubulin—are highly conserved in different cell types, the constituent proteins of IF can vary greatly in amino acid sequence and length (40–200 K). This peculiar property led originally to much confusion as to the ...
The main constituent of the ring polymers present in the cartwheel is the evolutionarily conserved SAS-6 protein family. SAS-6 proteins harbor a globular N-terminal head domain followed by a coiled-coil domain and an unstructured C-terminal moiety8,9. Through their coiled coil, SAS-6 proteins...