1.5.4Databases for structural classification of proteins Murzin et al. (1995)constructed theSCOPdatabase, which provides a detailed and comprehensive description of the structural and evolutionary relationships of the proteins of known structures. For each protein, the classification ha...
Over the past years several protein classifications have been developed that aim to group proteins based on their structural relationships. Some of these classification schemes explore the concept of structural neighbourhood (structural continuum), whereas other utilize the notion of protein evolution and ...
SCOP: a structural classification of proteins database for the investigation of sequences and structures. J. Mol. Biol. 247, 536–540 (1995). Article CAS PubMed Google Scholar Orengo, C. A. et al. CATH–a hierarchic classification of protein domain structures. Structure 5, 1093–1109 (...
In a second test, we quantify the ability of the significance score of the alignments to recognize structural and evolutionary relationships. As a benchmark we use a representative set of the SCOP (structural classification of proteins) database, with similarities ranging from closely related ...
Based on the type, amount and arrangement of the secondary structural elements, a protein can be classified into several structural classes. Structural Classification of Proteins (SCOP) [4] is a manually annotated database and has been regarded as the most accurate classification of protein structura...
Orengo CA, Michie AD, Jones S, Jones DT, Swindells MB, Thornton JM: CATH--a hierarchic classification of protein domain structures. Structure 1997, 5: 1093–1108. 10.1016/S0969-2126(97)00260-8 Article CAS PubMed Google Scholar Levitt M, Chothia C: Structural patterns in globular proteins...
Classification of protein groups with considerably lower (25–40%) homology remained more challenging18,28,29, while recent investigations seem to have successfully overcome the 80% accuracy barrier even for the low homology datasets30,31. A number of mathematical approaches has been utilized, ...
Protein structure classification and comparison is a central area in the field of bioinformatics. Rapidly increasing protein structure databases commonly suffer from the 'curse of dimensionality', necessitating the development of the dimensionality reduction of structural information prior to its classification...
PROTEIN FOLD RECOGNITION BASED ON STRUCTURAL CLASSIFICATION基于结构分类的蛋白质折叠模式识别方法蛋白质折叠模式识别结构分类平均势SCOPThreading对用于折叠模式识别的蛋白质结构数据库进行结构分类,构建了四个分类库:Al-α库,Al-β库,α/β库,α+β库和一个总库,然后分别统计出不同灵敏度的匹配评估函数(平均势)....
Orengo CA, Michie AD, Jones S, Jones DT, Swindells MB, Thornton JM: CATH-a hierarchic classification of protein domain structures. Structure. 1997, 5 (8): 1093-1108. 10.1016/S0969-2126(97)00260-8. Article CAS PubMed Google Scholar Sonnhammer EL, Eddy SR, Durbin R: Pfam: a comprehe...