Structural Biology of the Zika Virus. Trends in Biochemical Sciences 2017.Y. Shi and G. F. Gao, "Structural Biology of the Zika Virus," Trends in Biochemical Sciences, vol. 42, no. 6, pp. 443-456, 2017.Y. Shi, G.F. Gao, Structural biology of the Zika virus, Trends Biochem. ...
Zika virus (ZIKV) is an enveloped, icosahedral flavivirus that has structural and functional similarities to other human flavivirus pathogens such as dengue (DENV), West Nile (WNV) and Japanese encephalitis (JEV) viruses. ZIKV infections have been linked to fetal microcephaly and the paralytic Gui...
Zika virus is a member of the Flavivirus genus that had not been associated with severe disease in humans until the recent outbreaks, when it was linked to microcephaly in newborns in Brazil and to Guillain–Barré syndrome in adults in French Polynesia.
The structures of SARS-CoV-2, SARS-CoV (PDB: 6NUR),58 EV71 (PDB: 5F8I),34 poliovirus (PDB: 3OL8),35 HCV (PDB: 4WTI),33 Zika virus (PDB: 5TMH),59 vesicular stomatitis virus (PDB: 5A22),60 influenza virus (PDB: 4WRT),61 Lassa virus (PDB: 6KLC), Machupo virus (PDB: ...
Figure 1: Cryo-EM structure of immature Zika virus. Surface view (a,c) and cross-section (b,d) of mature (top)8 and immature ZIKV (bottom), colored radially according to the keys. Thick black arrows indicate the densities between the inner RNA core and the viral membrane (double-ended...
Virus structures are prominent examples of icosahedral symmetry in biology. Their architectures are currently modelled and classified in terms of the series of Goldberg polyhedra14—three dimensional solids with pentagonal and hexagonal faces—that provide a reference frame for the positions of the capsid...
The goal of computational biology in the early twenty-first century is to link the various genome sequencing projects to a high-throughput effort in comple... T Head-Gordon,JC Wooley - 《Ibm Systems Journal》 被引量: 45发表: 2001年 Integration of structural and functional genomics This paper...
Cryo-EM does not depend on generating crystals, and an ensemble of distinct conformations can be captured and identified. How has cryo-EM advanced structural biology? It essentially removed the crystallization bottleneck to get a structure. That opens up so many possibilities. Smaller proteins or ...
As the cells used in in-cell NMR are alive, intact and contain complete cellular compartments, the obtained information is therefore very useful in biology, as well as other fields, such as drug discovery. Although structural studies of membrane proteins in living cells are of great interest ...
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