Zika virus (ZIKV) is an enveloped, icosahedral flavivirus that has structural and functional similarities to other human flavivirus pathogens such as dengue (DENV), West Nile (WNV) and Japanese encephalitis (JEV) viruses. ZIKV infections have been linked
Predicting Zika virus structural biology: Challenges and opportunities for intervention. Antivir Chem Chemother. 2016; pii: 2040206616653873. 12. Gupta G, Lim L, Song J. NMR and MD Studies Reveal That the Isolated Dengue NS3 Protease Is an Intrinsically Disordered Chymotrypsin Fold Which Absolutely ...
Structural biology of Zika virus and other flaviviruses Nat. Struct. Mol. Biol., 25 (2018), pp. 13-20 CrossrefView in ScopusGoogle Scholar Hayes, 2009 E.B. Hayes Zika virus outside Africa Emerg. Infect. Dis., 15 (2009), pp. 1347-1350 CrossrefView in ScopusGoogle Scholar Heinz and ...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the COVID-19 pandemic. 2′-O-RNA methyltransferase (MTase) is one of the enzymes of this virus that is a potential target for antiviral therapy as it is crucial for RNA cap form
Nature Structural & Molecular Biology volume 28, pages 319–325 (2021)Cite this article 35k Accesses 111 Altmetric Metrics details Abstract The COVID-19 pandemic caused by nonstop infections of SARS-CoV-2 has continued to ravage many countries worldwide. Here we report that suramin, a 100-...
The goal of computational biology in the early twenty-first century is to link the various genome sequencing projects to a high-throughput effort in comple... T Head-Gordon,JC Wooley - 《Ibm Systems Journal》 被引量: 45发表: 2001年 Integration of structural and functional genomics This paper...
Figure 1: Cryo-EM structure of immature Zika virus. Surface view (a,c) and cross-section (b,d) of mature (top)8 and immature ZIKV (bottom), colored radially according to the keys. Thick black arrows indicate the densities between the inner RNA core and the viral membrane (double-ended...
Structural biology of flavivirus NS1 protein and its antibody complexes 2024, Antiviral Research Citation Excerpt : However, the presence of lipids in sNS1 hexamer eluded crystallization trials (Akey et al. 2015). With the resolution revolution in cryoEM (Chari and Stark 2023), several groups hav...
The main theme of my lab is the structural biology of cell surface receptors that mediate intracellular signaling and communication. We employ primarily cryo-EM 3D reconstructions complemented by biochemistry, biophysics, and simulation methods to obtain a dynamic view into the macromolecular complexes ca...
The flavivirus NS1 protein: Molecular and structural biology, immunology, role in pathogenesis and application as a diagnostic biomarker. Antiviral Res. 2013;98(2):192–208. 13. Youn S, Li T, McCune BT, Edeling MA, Fremont DH, Cristea IM, Diamond MS. Evidence for a genetic and physical...