Midostaurin dose adjustment is not necessary with concomitant strong CYP3A4 inhibitors in patients with FLT3 -mutated AML; however, caution is advised, and patients should be closely monitored.doi:10.1007/s00280-022-04448-wSechaud, RomainNovartis Pharma AG, Basel, SwitzerlandSinclair, Karen...
HLA-I complexes were purified from about 5 × 108 cell pellets after lysis with 0.25% sodium deoxycholate, 0.2 mm iodoacetamide, 1 mm EDTA, 1:200 Protease Inhibitors Mixture (Sigma), 1 mm PMSF, and 1% octyl-β-D glucopyranoside (Sigma) in PBS at 4°C for 1 h. The lysates were ...
Concomitant Use of Midostaurin with Strong CYP3A4 Inhibitors: An Analysis from the Ratify Trial - ScienceDirectTaoufik Ouatas PhD *Vincent Duval PharmD *Karen Sinclair PhD *Noah Berkowitz MD PhD *
We dispense drugs to haematological outpatients whose treatments can combine alfuzosin (for lower urinary tract symptoms, LUTS) with anti-infective drugs that may be strong CYP 3A4 inhibitors. We conducted a pharmaceutical intervention (PI) but lacked a clear and consensual management for physicians....
Dosing Recommendations of Aripiprazole Depot with Strong Cytochrome P450 3A4 Inhibitors: A Relapse RiskHuman Immunodeficiency VirusBipolar DisorderAripiprazoleRitonavirSaquinavirA 50-year-old male patient with comorbid human immunodeficiency virus developed a relapse of bipolar disorder after a switch from oral...