Clinical Impact: Decreased exposure of dexlansoprazole when used concomitantly with strong inducers [see CLINICAL PHARMACOLOGY]. Intervention: St. John’s Wort, rifampin: Avoid concomitant use with DEXILANT. Ritonavir-containing products: See prescribing information. CYP2C19 or CYP3A4 Inhibitors Clinical Im...
If unable to avoid coadministration with moderate CYP3A inhibitors, modify tazemetostat dose Strong and moderate CYP3A inducers Avoid coadministration Coadministration with a strong or moderate CYP3A inducer may decrease tazemetostat plasma concentrations, which may decrease the efficacy of tazemetostat...
Strong CYP3A4/5 Inhibitors The concomitant use of strong CYP3A4/5 inhibitors should be avoided (e.g., ketoconazole, itraconazole, clarithromycin, atazanavir, indinavir, nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin, and voriconazole). Selection of an alternate concomitant medication with...
Tell your doctor if you are pregnant or plan to become pregnant before taking Xeljanz; it is unknown how it may affect a fetus. If you are pregnant, your name may be listed on a pregnancy registry to track the outcome of the pregnancy and to evaluate any effects of Xeljanz on the baby...
When administering CABOMETYX in combination with nivolumab for the treatment of advanced RCC, refer to the nivolumab prescribing information. Dosage Modifications For Coadministration With Strong CYP3A4 Inhibitors Reduce the daily CABOMETYX dose by 20 mg (for example, from 60 mg to 40 mg daily or ...
The starting dose of Invokamet is individualized based on the patient's current regimen. What Drugs, Substances, or Supplements Interact with Invokamet? Invokamet may interact with metformin, cationic drugs, topiramate or other carbonic anhydrase inhibitors,diuretics, corticosteroids, phenothiazines,thyroidpr...
Dose Modifications When Used With CYP3A4 Inhibitors SEROQUEL dose should be reduced to one sixth of original dose when co-medicated with a potent CYP3A4 inhibitor (e.g., ketoconazole, itraconazole, indinavir, ritonavir, nefazodone, etc.). When the CYP3A4 inhibitor is discontinued, the dose ...
Velcade (bortezomib) is anantineoplastic(anticancer) agent used to treatmultiple myelomaand mantle celllymphoma, and is sometimes given after other cancer medications have been tried without successful treatment. What Are Side Effects of Velcade?
Dosing of Prograf is individualized based on clinical assessments of rejection and tolerability. What Drugs, Substances, or Supplements Interact with Prograf? Prograf may interact withchemotherapy, medicines to treat bowel disorder,antiviralmedications, pain orarthritismedicines, antibiotics, other medications...
Table 1 displays the recommended adult daily dosage of XELJANZ and XELJANZ XR and dosage adjustments for patients receiving CYP2C19 and/or CYP3A4 inhibitors, in patients with moderate or severe renal impairment (including but not limited to those with severe insufficiency who are undergoing hemodialysi...