Taken together, these results indicate that (I) laminin isoforms containing the γ2 chain can act as adhesive substrates for human haematopoietic cells, and (II) the laminin γ2 chain can be used as a specific marker molecule for human bone-marrow-derived stromal cells.Siler...
all hematopoietic origin fibroblast-like cells will be referred to as fibrocytes, although it is currently not clear whether they are all derived from the same leukocyte subtype through the same mechanism in vivo. Fibrocytes express the pan-hematopoietic cell marker CD45 along with CD11b and severa...
Cells in culture decrease their capacity of division in a regulated, structured manner, like the characteristic of a differentiation marker in a digressing system of differentiation divisions and proliferation [84] although it remains uncertain why progenitor cells are decreased during subcultivation. ...
Results of Reverse Transcription - Quantitative Polymerase Chain Reaction (RT-qPCR) demonstrated significant dose-dependent increase of the early marker RUNX2, and its known transcriptional targets ALP and OSX as early as day 3 (Figs 1c and 2a). Long-term treatment however, diminished this ...
通过对患者年龄、性别和肿瘤时期等多变量校正分析发现,基质marker gene表达增加时LUSC病人的存活率下降,而非LUAD病人(Fig.6d)。如flat AT1 cells, respiratory epithelial cells and cross-presenting dendritic cells高表达时LUSC病人存活率降低,而CD8+ T-cells cluster 8正好相反。
Haematopoietic stem cells (HSCs) are maintained by bone marrow niches in vivo1,2, but the ability of niche cells to maintain HSCs ex vivo is markedly diminished. Expression of niche factors by Nestin-GFP+ mesenchymal-derived stromal cells (MSCs) is downr
Taken together, these results indicate that (I) laminin isoforms containing the γ2 chain can act as adhesive substrates for human haematopoietic cells, and (II) the laminin γ2 chain can be used as a specific marker molecule for human bone-marrow-derived stromal cells. 展开 ...
The mesenchymal stem cell marker CD248 (endosialin) is a negative regulator of bone formation in mice ObjectiveCD248 (tumor endothelial marker 1/endosialin) is found on stromal cells and is highly expressed during malignancy and inflammation. Studies have s... AJ Naylor,E Azzam,S Smith,.....
Mesenchymal stromal/stem cells (MSCs) are widely utilized in cell therapy because of their robust immunomodulatory and regenerative properties. Their paracrine activity is one of the most important features that contribute to their efficacy. Recently, it
Bone marrow-derived mesenchymal stromal cells (BM-MSCs) in culture are derived from BM stromal cells or skeletal stem cells. Whereas MSCs have been exploited in clinical medicine, the identification of MSC-specific markers has been limited. Here, we repo