Taken together, these results indicate that (I) laminin isoforms containing the γ2 chain can act as adhesive substrates for human haematopoietic cells, and (II) the laminin γ2 chain can be used as a specific marker molecule for human bone-marrow-derived stromal cells.Siler...
all hematopoietic origin fibroblast-like cells will be referred to as fibrocytes, although it is currently not clear whether they are all derived from the same leukocyte subtype through the same mechanism in vivo. Fibrocytes express the pan-hematopoietic cell marker CD45 along with CD11b and severa...
Taken together, these results indicate that (I) laminin isoforms containing the γ2 chain can act as adhesive substrates for human haematopoietic cells, and (II) the laminin γ2 chain can be used as a specific marker molecule for human bone-marrow-derived stromal cells. 展开 ...
通过对患者年龄、性别和肿瘤时期等多变量校正分析发现,基质marker gene表达增加时LUSC病人的存活率下降,而非LUAD病人(Fig.6d)。如flat AT1 cells, respiratory epithelial cells and cross-presenting dendritic cells高表达时LUSC病人存活率降低,而CD8+ T-cells cluster 8正好相反。 小结 对5位肺癌患者共19个样本进行...
Results of Reverse Transcription - Quantitative Polymerase Chain Reaction (RT-qPCR) demonstrated significant dose-dependent increase of the early marker RUNX2, and its known transcriptional targets ALP and OSX as early as day 3 (Figs 1c and 2a). Long-term treatment however, diminished this ...
The mesenchymal stem cell marker CD248 (endosialin) is a negative regulator of bone formation in mice ObjectiveCD248 (tumor endothelial marker 1/endosialin) is found on stromal cells and is highly expressed during malignancy and inflammation. Studies have s... AJ Naylor,E Azzam,S Smith,.....
Bone marrow-derived mesenchymal stromal cells (BM-MSCs) in culture are derived from BM stromal cells or skeletal stem cells. Whereas MSCs have been exploited in clinical medicine, the identification of MSC-specific markers has been limited. Here, we repo
Balanced differentiation of mesenchymal stromal cells (MSCs) into osteoblasts and adipocytes is essential for healthy bone and fat homeostasis. A disturbed balance of MSC differentiation results in bone loss and increased adipogenesis as observed in several human conditions, such as osteoporosis, obesity,...
Methods. Phenotypic and functional criteria for the identification of adipose-derived cells were drawn from the literature. Results. In the SVF, cells are identified phenotypically by the following markers: CD45-CD235a-CD31-CD34+. Added value may be provided by both a viability marker and the ...
In multivariate analysis, AKR1C1 expression in carcinoma cells was an independent prognostic marker.ConclusionIt can be assumed that our observations are due to the independent regulatory function of AKR1C1/2 in progesterone metabolism and therefore provide a basis for new hormone-based therapy ...