Diarrhea that originates in the small intestine will cause a dog to defecate at their normal frequency or slightly more frequently. Usually, the stool is watery. A dog whose diarrhea is a large intestine issue, such as colitis, will have very frequent but small bowel movements. These dogs ma...
(social defeat model, acute restraint stress model, urethane-induced lung cancer model, colitis-associated colorectal cancer model); human or mouse cells in vitro Elevated plasma corticosterone and upregulated Tsc22d3 expression, which blocked type I interferon (IFN) responses in dendritic cell and ...
16S rRNA gene sequencing was performed to determine the gut microbiota in the colon, cecum and ileum. We found that antibiotics decreased the CUMS-induced increases in spleen coefficients. Short-term antibiotic exposure significantly increased the cecum and ileum microbiota richness and significantly ...
Inhibition of NF-κB prior to and during inflammation in intact dogs also reversed the suppression of contractility. Conclusions: Transcription factor NF-κB is activated in colonic circular muscle cells by inflammation and oxidative stress. This activation of NF-κB mediates the suppression of cell ...
Psychosocial stress is a critical inducing factor of inflammatory bowel diseases (IBD), while autophagy is a novel central issue of IBD development. The present study investigated the potential role of autophagy in stress-related IBD in patients and anim
Meanwhile, high-density treatments induced significant changes in the composition of gut microbiota by increasing disease-associated microbes. The levels of hormones and immunity (i.e., CORT, 5-HT, and IgG) elevated by the high density treatment were significantly correlated with some specific ...
DVDMS-PDT induced apoptosis via elevated ER stress and activation of the PERK/ATF4/CHOP/caspase cascade pathway in CX-1 cells. The endoplasmic reticulum was involved in the subcellular accumulation of DVDMS in CX-1 cells. Dual-luciferase reporting experiment confirmed that a direct crosslinking betw...
Fabia, R, Ar’Rajab. Willen, R, Marklund, S, and Andersson, R: The role of transient mucosal ischemia in acetic acid-induced colitis in the rat. J. Surg. Res., 63: 406–412, 1996. ArticlePubMed Ishimoto, H, Natori, M, Tanaka, M, Miyazaki, T, Kobayashi, T, and Yoshimura, Y:...
“Impairment of mitochondrial acetoacetyl CoA thiolase activity in the colonic mucose of patients with ulcerative colitis”, Free Radical Research Communications, 1993, 18(2):115-122, abstract only. Sehirli, O et al. “Antioxidant effect of alpha-lipoic acid against ethanol-induced gastric ...
19. A method of reducing stress induced immunological dysregulation in an animal, said method comprising the administration to said animal a composition according to claim 1. 20. A method for providing nutritional support to a stressed individual comprising the administration of a composition according...