The merger of these companies has an immediate impact, reducing the number of competing research and development groups; such changes often cause a strategic review of the therapeutic areas of research and development, where development of new antibiotics must compete with other areas that may be ...
A large number of antibacterial drugs (69%) approved in 1981–2006 are either natural compounds or have been developed from nature derived scaffolds. The current pipeline of antibiotics is relatively dry with very few compounds available to revolutionize antibacterial therapy, especially in the...
This is an insiders account of 50 years of genetic studies of the soil-inhabiting microbes that produce most of the antibiotics used to treat infections, a... JC Yi,SJ Chapman,JA Buswell,... 被引量: 0发表: 2008年 Streptomyces in Nature and Medicine: The Antibiotic Makers (review) The ...
摘要: Journal of Antibiotics, official journal of the Japan Antibiotics Research Association, is a print and online publication that focuses on research on antibiotics and related types of medicinal substancesDOI: 10.1038/ja.2014.85 被引量: 3 ...
Soil microbiota can confer fitness advantages to plants and increase crop resilience to drought and other abiotic stressors. However, there is little evidence on the mechanisms correlating a microbial trait with plant abiotic stress tolerance. Here, we r
Streptomyces are a genus of ubiquitous soil bacteria from which the majority of clinically utilized antibiotics derive1. The production of these antibacterial molecules reflects the relentless competition Streptomyces engage in with other bacteria,
rochei 7434AN4, which produces two structurally unrelated polyketide antibiotics, lankacidin and lankamycin (Figure 1). Physical analysis revealed that pSLA2 is 17 kb in size and is structurally similar to adenovirus and bacteriophage φ29 DNA; TIRs are present at both ends and a terminal ...
Streptomyces is a genus of gram-positive bacteria with a mycelial growth habit and the ability to produce spores. Due to their unparalleled ability to produce antibiotics, most of the early research carried out on Streptomyces was antibiotic discovery-dr
Streptomyces species are considered as antibiotic factories (Barka et al., 2015), being responsible for the production of more the half of all known antibiotics like tetracyclines, chloramphenicol, streptomycin, and clavulanic acid, among others compounds. The genus is also a bountiful source of ...
β-Lactam antibiotics are therefore activated amides that are more easily hydrolyzed than regular amide bonds. Nevertheless, the substrate efficiency can be drastically modulated by the nature of side chain derivatives (R and/or R') that are linked to the basal structure, 6-APA or 7-ACA (Fi...