Of the four standard TB antibiotics used in “short course” treatment (HRZE), only Rifampin, which inhibits bacterial RNA polymerase, is a broad-spectrum antimicrobial that is used for non-mycobacterial infections. The effects of this prolonged antibiotic regimen on the intestinal microbiota are ...
Cells were cultured in complete media consisting of Dulbecco’s Modified Eagle’s medium (DMEM):F12 with 10% fetal bovine serum and 1% penicillin and streptomycin at 37 °C in 5% CO2 and saturated moisture. Cells were maintained for a maximum of 30 days before being discarded60. The ...
Molecular Epidemiology of Antibiotic Resistance Genes in Multiresistant Epidemic Salmonella typhimurium DT 104 (3")-Ia, responsible for resistance to streptomycin and spectinomycin; the 1.2 kb amplicon contained the gene blaPSE-1, encoding the beta-lactamase PSE-... A Ridley,EJ Threlfall - 《Micro...
A. allosaccharophila strain AE59-TE2 produced antimicrobial activity against a broad range of bacteria, including important gram-negative bacteria, not typically targeted by bacteriocins. Herewere described novel zoocin genes that are promising for industrial applications in the food and health sectors...
This forms a narrow central channel through which potassium ions (K+) can flow out of the cell. Each KV subunit forms an identical quarter of the tetramer structure about the selectivity filter region central pore. The KV2.1 homotetramer model reveals the side chains of the Valine and ...
Initial observations with vancomycin-induced cardioprotection have been subsequently confirmed in a study showing infarct size limitation in rats after administration of a mixture of streptomycin, bacitracin, polymixin B, and neomycin [5]. Of note, antibiotic-induced cardioprotection has been associated ...
Some antibiotics such as Penicillin G are 'narrow spectrum', which means that they are only effective against a limited rage of bacteria. 'Broad spectrum' antibiotics such as Tetracycline are effective against a wide range of organisms.1 Antibiotics are used to treat humans as well as animals....
The transcriptional control of sporulation in Bacillus subtilis is reasonably well understood, but its translational control is underexplored. Here, we use RNA-seq, ribosome profiling and fluorescence microscopy to study the translational dynamics of B.
Intensive studies have unveiled a multitude of mechanisms of action underlying such drug resistance in addition to drug-specific targets, such as efflux pumps23 of MFS family24–28, ABC family29–31 and RND Family32. These efflux proteins can mediate broad-spectrum resistance to streptomycin, ...
(Fig.4c). In bacteria, FRET fluctuations associated with proofreading selection are hypothesized to represent attempts of its CCA-end to navigate the LSU accommodation corridor—a narrow passageway through the A-loop major groove—en route to the PTC8,42(Extended Data Fig.5e–g). In human, ...