Specifically, a multivalent Streptococcus pneumoniae immunogenic composition is provided comprising 10 or more capsular saccharides from different S. pneumoniae serotypes which are conjugated to a carrier protein, and comprising 3 or more different carrier proteins, wherein the composition comprises:serotype...
PREVALENCE OF STREPTOCOCCUS PNEUMONIAE SEROTYPES OF THE HEPTAVALENT CONJUGATED VACCINE IN PEDIATRIC INFECTIONSSevere evolution of pneumococcal infections with multiresistant strains in children under 2 years of age determined the introduction, in some countries, of the heptavalent vaccine, which includes ...
Streptococcus pneumoniae, a gram-positive bacterium with over 90 serotypes, is the most common causative agent. Moreover, comorbid factors including heart failure, renal disease, and pulmonary disease could increase the risk of pneumococcal pneumonia. Since the advent of the pneumococcal vaccine in ...
Since children under 2 years of age do not have immunologic responses to polysaccharide vaccines, a conjugate pneumococcal vaccine was developed. This vaccine contains the capsular polysaccharide antigens of the seven serotypes that most commonly cause invasive disease in children (4, 6B, 9V, ...
We have conducted a 1-year longitudinal study in mice vaccinated by free serotype 4 Streptococcus pneumoniae PS (PS4), the corresponding tetanus toxoid (TT... F Deauvieau,S Dussurgey,D Rossignol,... - 《Vaccine》 被引量: 16发表: 2010年 IMPROVED PREPARATION OF VACCINES AGAINST STREPTOCOCCUS...
Isolates ofS. pneumoniaeare traditionally characterized in terms of the chemical composition of theirpolysaccharidecapsules of which there are more than 90serotypes. Different serotypes display differentpathogenic potentialand geographic distribution (Brueggemann et al., 2003; Henriques-Normark et al., 2008...
STREPTOCOCCUS PNEUMONIAE is the most common cause of both pneumonia overall and fatal pneumonia. Antibiotic resistance has developed worldwide and is most frequent in pneumococcal serotypes that are most prevalent in children (types/groups 6, 14, 19, and 23). The incidence of pneumococcal...
Screening for Th17-Dependent Pneumococcal Vaccine Antigens: Comparison of Murine and Human Cellular Immune Responses Conjugate vaccines against Streptococcus pneumoniae have significantly reduced diseases caused by serotypes included in those vaccines; however, there is s... YJ Lu,E Oliver,F Zhang,......
Streptococcus pneumoniae (pneumococcus) is a leading vaccine-preventable cause of childhood invasive disease. Nigeria has the second highest pneumococcal disease burden globally, with an estimated ~49000 child deaths caused by pneumococcal infections each year. Ten-valent pneumococcal conjugate vaccine (GSK...
Streptococcus pneumoniae: proteomics of surface proteins for vaccine development Morsczeck C,Prokohova T,Sigh J, et al.Streptococcus pneumoniae: proteomics of surface proteins for vaccine development.Clinical Microbiology and Infection. ... C Morsczeck,T Prokhorova,J Sigh,... - 《Clin Microbiol ...