In non-excitable cells including astrocytes and gliomas, store-operated calcium channels (SOCC) are the major Caentry pathway. Recently, we have shown that SOCC activity is much larger in human GBM cells and cell lines as compared to normal human astrocytes. In this study, we have ...
Store-operated calcium channels (SOCC) are highly Ca2+-selective cation channels and have crucial effects on the immune system. It has been indicated that BTP2, a potent SOCC blocker, could inhibit pro-inflammatory cytokine production from immune cells both in vitro and in vivo. Therefore, this...
To refill the depleted Ca2+stores in theSR, another type of Ca2+channels in the cell membrane, known as store‐operated Ca2+channels (SOCC), are activated. TheseSOCCs are verapamil and nifedipine resistant, but areSKF96465 (SK) and gadolinium (Gd3+) sensitive. BothSKand Gd3+have been ...
Ca(2+) influx triggered by depletion of sarcoplasmic reticulum (SR) Ca(2+) stores [mediated via store-operated Ca(2+) channels (SOCC)] was characterized in... B Ay,YS Prakash,CM Pabelick,... - 《Am J Physiol Lung Cell Mol Physiol》 被引量: 273发表: 2004年 An siRNA screen for ...
TRPC1 stimulates calciumsensing receptorinduced storeoperated Ca2+ entry and nitric oxide production in endothelial cells Storeoperated Ca2+ entry (SOCE) via storeoperated Ca2+ channels (SOCC), encoded by transient receptor potential canonical (TRPC) channel proteins, is an im... YY Qu,LM Wang,H...
TRPC1 Is Required for Functional Store-operated Ca[sup 2+] Channels.Examines the role of TRPC1 in store-operated calcium influx channel (SOCC) function. Effect of the overexpression of TRPC1 on SOCC activity in human submandibular gland (HSG) cells; Interaction of expressed TRPC1 proteins with...
INAD is a photoreceptor cell-specific protein (Shieh and Neimeyer 1995) that binds to the TRP store-operated Ca2+ channel (SOCC) (45, 18). The demonstration that INAD interacts with TRP and that disruption of this interaction results in an abnormal light response has led to the suggestion...
This observation indicated that after depletion of Ca2+ from Sarcoplasmic reticular, SOCC got activated and in the presence of 2-APB, response was significantly reduced. Thus implying the functional involvement of store-operated calcium channels in myometrium of non-pregnant buffaloes.Sharma, Abhishek...
Aging related change in store-operated Ca~(2+) influx of mouse sinoatrial node in conduction velocity which result in arrhythmias.We recently discovered that store-operated Ca~(2+) channel(SOCC)activity is present in the mouse sinoatrial node leading to Ca~(2+) entry.In the present study we...
Calcium channel blockade could therefore limit the inflammatory response to shock, but current calcium channel blockers target L-type channels and thus can exacerbate shock. PMN Ca2+ mobilization however, occurs via store-operated calcium channels (SOCC) that can be targeted selectively. We ...