英文名称: STING agonist-17 总访问: 118 国产/进口: 进口 半年访问: 45 产地/品牌: MedChemExpress(MCE) 产品类别: 生化试剂 规格: 1 mg; 5 mg 最后更新: 2025-2-13 货号: HY-143320 CAS 号: 2816929-47-0 参考报价: 2500; 6200 立即询价 电话咨询 ...
2025年3月10日，复旦大学附属华山医院刘杰教授、骆菲菲研究员团队在Cancer Cell发表题为“Targeting tumor monocyte-intrinsic PD-L1 by rewiring STING signaling and enhancing STING agonist therapy”的研究论文，揭示了STING激动剂诱导单核细胞内源性PD-L1介导免疫抑制的全新机制，并提出通过STING信号重编程提升治疗疗...
近期,美国密歇根大学James J. Moon教授团队在《Journal of Controlled Release》期刊2023年第357期发表了题为“Unlocking the promise of systemic STING agonist for cancer immunotherapy”的综述文章,对系统性递送STING激动剂用于肿瘤免疫治疗进行了总结和...
AMM研究｜脂质磷酸钙纳米粒递送STING激动剂用于增强神经 近日，首都医科大学附属北京儿童医院药学部梅冬团队，在Acta Materia Medica上发表了题为“STING agonist delivery by lipid calcium phosphate nanoparticles enhances immune activation for neuroblastoma"的研究论文（http://doi.org/10.15212/AMM-2023-0011）。神...
Ruochen Zang,et al, Tao Jiang. Design and syntheses of a bimolecular STING agonist based on the covalent STING antagonist. Eur J Med Chem. 2023, 250:115184. doi: 10.1016/j.ejmech.2023. 声明:发表/转载本文仅仅是出于传播信息的需要...
(100 nmol) or 100 nmol of ADU-S100, a STING agonist currently in clinical trials. As shown in Fig.4a,b, the LND-CDNs were strikingly effective, eliciting tumour regression and complete responses in 75% of the animals, while the free CDN compounds at either dose were completely ...
此外,MSA-2易于口服给药,由于方便和成本低,这是一种理想的给药途径。相关研究结果发表在2020年8月21的Science期刊上,论文标题为“An orally available non-nucleotide STING agonist with antitumor activity”。 打开凤凰新闻,查看更多高清图片 STING激动剂MSA-2,图片来自Science, 2020, doi:10.1126/science.aba6098...
An intravenous STING agonist enhances the efficacy of radiation therapy Our data suggest that STING regulates the amount of DNA damage and thus tumor cell survival, a finding that is relevant for most patients with locally advanced HNSCC. We therefore asked whether STING activation with a next-gene...
STING deletion was associated with increased Th17 cell infiltration in the pancreas, whereas STING agonist limited this Th17 response. Importantly, anti-IL-17A antibody treatment mitigated the severity of CP in the absence of STING signalling. STING deficiency promoted Th17 polarisation and PSCs ...
总之,这项工作强调了纳米颗粒结构和纳米生物相互作用在控制免疫疗法疗效方面的重要性。相关工作以“Investigation of the enhanced antitumour potency of STING agonist after conjugation to polymer nanoparticles”为题发表在Nature Nanotechnology...