Sterol 27-hydroxylase deficiency: a rare cause of xanthomas in normocholesterolemic humans. Trends Endocrinol Metab 2000;11:180-183.Ingemar Björkhem,Eran Leitersdorf.Sterol 27-hydroxylase Deficiency: A Rare Cause of Xanthomas in Normocholesterolemic Humans[J]. Trends in Endocrinology & Metabolism...
Matthias Johannes ReddehaseBundesforschungsanstalt für Viruskrankheiten der Tiere, TubingenJames Hilton CoxBundesforschungsanstalt für Viruskrankheiten der Tiere, TubingenUlrich Helmut KoszinowskiBundesforschungsanstalt für Viruskrankheiten der Tiere, TubingenAtherosclerosis Supplements...
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Sterol 27-hydroxylase (CYP27) is a ubiquitously expressed enzyme involved in cholesterol metabolism. Notably, its deficiency causes a disease characterized by progressive neurologic impairment. With the final goal to understand the pathophysiological role of CYP27A1 in the CNS, we studied the ...
In man, hepatic mitochondrial sterol 27-hydroxylase and microsomal cholesterol 7α-hydroxylase initiate distinct pathways of bile acid biosynthesis from cholesterol, the "acidic" and "neutral" pathways, respectively. A similar acidic pathway in the rat has been hypothesized, but its quantitative importan...
Transfection of mutant cDNAs into cultured cells results in the synthesis of immunoreactive sterol 27-hydroxylase protein with greatly diminished enzyme activity. We have localized the CYP27 gene to the q33-qter interval of human chromosome 2, and to mouse chromosome 1, in agreement with the ...
Sterol 27-hydroxylase mRNA, mass and specific activity were not affected by thyroxine (1.0 microM), dibutyryl-cAMP (5O microM), nor squalestatin 1 (15O nM-1.0 microM), an inhibitor of cholesterol biosynthesis. Taurocholate (50 microM), however, repressed sterol 27-hydroxylase mRNA levels by ...
A method for preventing or reducing restenosis wherein a 27- hydroxycholesterol or a 25,26 and/or 27-aminocholesterol, or a sterol 27- hydroxylase stimulant, is administered in a restenosis preventing and/or reducing amount. The invention also includes a method for treating cancer using 27-hydro...
An autopsy case of gallbladder cancer developing in a Japanese man with cerebrotendinous xanthomatosis: genetic analysis of the sterol 27-hydroxylase and ... H Kato,S Koyabu,S Aoki,... - 《Pathology》 被引量: 15发表: 2003年 Cerebrotendinous xanthomatosis: case report with evidence of oxidat...
Fibrates suppress bile acid synthesis via PPARα-mediated down-regulation of cholesterol 7α-hydroxylase and sterol 27-hydroxylase gene expression 喜欢 0 阅读量: 23 作者:S. M. Post,B. Staels,E. de Fabiani,J. Y. L. Chiang,M. Crestani ...