Wikvall, K. ( 1993 ) Sterol 26-hydroxylase , Handb. Exp. Pharmacol. 105 , 705 – 718 .Wikvall, K. 1993. Sterol 26-hydroxylase. In Cytochrome P-450: Handbook of Experimental Pharmacology. J. B. Schenkman, and H. Greim, editors. Springer Berlin. Vol. 105. 705-718....
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Notably, we identified (25R)26,7α- and (25S)26,7α-dihydroxy epimers of oxysterols and cholestenoic acids, indicating the presence of an additional sterol 26-hydroxylase in mouse. Importantly, our analysis also revealed elevated levels of 7α-hydroxycholest-4-en-3-one, which we found ...
Elimination of cholesterol as cholestenoic acid in human lung by sterol 27-hydroxylase: evidence that most of this steroid in the circulation is of pulmona... Human alveolar macrophages have exceptionally high capacity to convert cholesterol into 27-hydroxycholesterol and cholestenoic acid by the stero...
Cholecalciferol is then metabolized in the liver by the enzyme 25-hydroxylase encoded by the CYP2R1 gene and converted to 25-hydroxyvitamin D3, which is transported through the blood to the kidney, where it is transformed by the enzyme, 1-α-hydroxylase, synthesized by the CYP27B1 gene, to...
25- and 26-Hydroxylation of 5β-cholestane- 3α,7α,12α-triol by reconstituted systems from rat liver microsomes. J Biol Chem 251: 3495–3499 PubMed CAS Google Scholar Bjorkhem I, Fausa O, Hopen G, Oftebro H, Pedersen JI, Skrede S (1983) Role of the 26-hydroxylase in the ...
7alpha-Hydroxycholest-4-en-3-one is a ligand for the pregnane X receptor (PXR), activation of which is known to up-regulate the expression of CYP3A11, which we confirm has sterol 26-hydroxylase activity. This can explain the formation of (25R)26,7alpha- and (25S)26,7alpha-dihydroxy ...
The stimulatory effect of sterol carrier protein2 was much less with purified cholesterol 7 alpha- and 26-hydroxylase systems than with microsomes and mitochondria. No stimulatory effect of sterol carrier protein2 was observed with purified 12 alpha-hydroxylase and 3 beta-hydroxy-delta 5-C27-steroid...
A method for preventing or reducing restenosis wherein a 27-hydroxycholesterol or a 25,26 and/or 27-aminocholesterol, or a sterol 27-hydroxylase stimulant, is administered in a restenosis preventing and/or reducing amount. The invention also includes a method for treating cancer using 27-...
JAVITT Norman B. New York University MedicalEPUS5376652 * Nov 30, 1993 Dec 27, 1994 New York University Medical Center Administration of a 27-hydroxycholesterol or related compound or sterol-27-hydroxylase stimulant to prevent restenosis following vascular endothelial injury...