In Plenum: NewYork, 1993; pp 429-501.Casy, A. R,Dewar, G. H.The steric factor in medicinal chemistry. Dissymmetric probes of pharmacological receptors. . 1993Casy AF (1993) The steric factor in medicinal chemistry: dissymmetric probes of pharmacological receptors. Oxford: Plenum Press....
Alan F. Casy to bring in these pages a clear and comprehensive view of medicinal stereochemistry, a discipline in which he has been active and successful for many years both as a teacher and a researcher. Written for graduate students and research workers in medicinal chemistry and pharmacology,...
What is a steric factor in organic chemistry? Conformation Different conformations of a molecule arise from the different possible arrangements of atoms around the central atom. These conformations however interconvertible by mere rotation of bonds at low temperatures. ...
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- 《Inorganic Chemistry》 被引量: 197发表: 2002年 Structure-based prediction of the stability of transmembrane helix-helix interactions: The... Presents a study in which structure-based empirical parameters representing steric clashes and restrictions of side- chain rotamer freedom, was used to exp...
In our present work we have succeeded for the first time to enmark the energy of exciplex (E ex) as the prime factor in determining the epsiv max. We have indicated a definite inverse correlation (1:1) between epsiv max and E ex. We have also tried to correlate some parameters that ...
Steric factor Steric crowding Steric strain (or steric tension) Steric interactions, whether between electrons or atoms, always result in a rise in the energy of a system. Systems with higher energies are more unstable than systems with lower energies. Figure 1 depicts cyclohexane conformations as ...
- 《Journal of Medicinal Chemistry》 被引量: 370发表: 1997年 The Clinical Relevance of the miR-197/CKS1B/STAT3-mediated PD-L1 Network in Chemoresistant Non-small-cell Lung Cancer Programmed cell death ligand-1 (PD-L1) has recently gained considerable attention for its role in tumor immune ...
© 2007 Springer-Verlag About this entry Cite this entry (2007). Steric factor. In: Gooch, J.W. (eds) Encyclopedic Dictionary of Polymers. Springer, New York, NY. https://doi.org/10.1007/978-0-387-30160-0_11016 Download citation ...