As well as their unique properties, different molecules have different geometries. You can use valence shell electron pair repulsion alongside thesteric numberof a molecule to determine its geometric structure. This is one of the reasons that understanding what the steric number of a molecule is and...
M. Looking beneath the surface to determine what makes DNA damage deleterious. Curr. Opin. Chem. Biol. 21, 48–55 (2014). Article CAS PubMed Google Scholar Schaaper, R. M., Kunkel, T. A. & Loeb, L. A. Infidelity of DNA synthesis associated with bypass of apurinic sites. Proc....
While you can't use VSEPR to calculate bond angles, it helps determine those angles based on steric number. Only hydrogen has a steric number of one, and the H2 molecule has a linear shape. Hybridized Orbitals An electron orbits an atom in a characteristic shape determined by the most likel...
With Rh/PPh3 and Rh/dppe, concerted C−C bond cleavage and Rh-carbenoid formation determine the regioselectivity. In the Rh/PPh3 case, the key difference between the two competing transition states is the skeletal deformation. The internal carbenoid formation transition state is favored due to ...
The general theory of these reactions involves careful analysis of such properties as the electron affinity of key atoms, bond strengths and steric hindrance. These issues can determine the relative stability of short-lived reactive intermediates, which usually directly determine the path of the ...
It is exactly opposite to the situation in most aqueous systems for which the solvating agent (the water molecules) is in excess and the number of ions correlates instead with the amount of the dissociating agent. In order to determine the size of these "stericaly stabilized" ions we use ...
Unfortunately, because these are enzymatic reactions, it will be difficult to determine whether the effects are predominantly on the binding enthalpy or the entropy. In an attempt to establish whether the altered affinities of restricted ligands arise primarily from enthalpic or entropic effects, my ...
Finally, we used microscale thermophoresis (MST) to determine the dissociation constant (Kd) of the complexes. A Kd value of ~10 µM was determined for the system formed by ABD2 with both types of bicelles (Fig. S2C and D). To investigate the potential 3D structural modifications of ...
Prion-like low-complexity domains (PLCDs) have distinctive sequence grammars that determine their driving forces for phase separation. Here we uncover the physicochemical underpinnings of how evolutionarily conserved compositional biases influence the ph
Accordingly, we constructed several structural models of potential post-Pi-release configurations, to determine whether EF-Tu-accelerated elbow accommodation is robust to the conformation of EF-Tu. In the pre-Pi-release conformation of ternary complex20–24, the 30-CCA end of aa-tRNA binds to a...