2020年,华大自主研发出超高分辨率的“生命全景照相机”Stereo-seq(Spatial Enhanced REsolution Omics-sequencing),该技术基于DNA纳米球测序芯片,实现了500 nm的分辨率,同时捕获面积可达13 cm×13 cm。 目前,Stereo-seq已被成功应用到胚胎和器官发育、再生医学、肿瘤研究等多个领域,相关成果分别以专题和封面文章形式发表...
2020年,华大自主研发出超高分辨率的“生命全景照相机”Stereo-seq(Spatial Enhanced REsolution Omics-sequencing),该技术基于DNA纳米球测序芯片,实现了500 nm的分辨率,同时捕获面积可达13 cm×13 cm。 目前,Stereo-seq已被成功应用到胚胎和器官发育、再生医学、肿瘤研究等多个领域,相关成果分别以专题和封面文章形式发表...
2020年,华大自主研发出超高分辨率的“生命全景照相机”Stereo-seq(Spatial Enhanced REsolution Omics-sequencing),该技术基于DNA纳米球测序芯片,实现了500 nm的分辨率,同时捕获面积可达13 cm×13 cm。 目前,Stereo-seq已被成功应用到胚胎和器官发育、再生医学、肿瘤研究等多个领域,相关成果分别以专题和封面文章形式发表...
DNBSEQ™ Technology Platforms BGI Genomics' sequencing services are typically executed with proprietary DNBSEQ™ sequencing technology platforms, for great sequencing data at some of the lowest costs in the industry. DNBSEQ™ can offer advantages in terms of lower amplification error rates and much...
DNB 微阵列芯片 Stereo-seq(spatial enhanced resolution om- ics-sequencing) 是华大研究院基于 DNB(DNA nanoball) 阵列芯片和原位捕捉技术自主研发的具 有更高分辨率的空间转录组技术.DNB 纳米球微 阵列芯片首先将含有随机条形码序列的 DNB 沉积 到经光刻蚀刻的经修饰的芯片上.每个 DNB 的直 径约为 220 nm, ...
我们以在世界范围内广泛分布的模式植物拟南芥叶片为研究对象,充分利用植物细胞具有细胞壁的特征,基于Stereo-seq技术开发了广泛适用于植物组织的scStereo-seq(single-cell SpaTial Enhanced REsolution Omics-sequencing)技术,实现了真正的空间单细胞转录组研究。一方面突破了长期以来研究人员无法对叶片中高度相似细胞类型的分子...
BGI-Research in 2013. Chen spent his first years at the company as part of the team that developed the DNA nanoball technology (DNB-seq) which is used in MGI’s sequencers. Part of the progress they made was maximizing the density of the nanoballs and developing the largest sequencing ...
Tissue preparation, cryosection, stereo-seq library preparation, and sequencing Stereo-seq is a state-of-art spatial transcriptome platform that captures mRNA from tissue sections using stereo chips. This technology achieves nanoscale resolution with a spot diameter of 220 nm, enabling the most deta...
Recent advances in single-cell or single-nucleus RNA sequencing (sc/snRNA-seq), along with spatial transcriptomics, have revealed remarkable molecular diversity in the cellular landscapes of brains under NA and AD. For instance, the first snRNA-seq study on human AD conducted by Mathys et al.13...
Among all in situ gene expression methodologies, Stereo-seq (spatial enhanced resolution omics sequencing) is so far the only sequencing-based spatially resolved transcriptomics technology with subcellular resolution (Chen et al., 2021), based on which we set out to accomplish in situ single-cell ...