During the last two decades, the profusion of HIV research due to the urge to identify new therapeutic targets has led to a wealth of information on the retroviral replication cycle. However, while the late stages of the retrovirus life cycle, consisting of virus replication and egress...
Analysis of the earliest steps of hepadnavirus replication: genome repair after infectious entry into hepatocytes does not depend on viral polymerase activ... Kock J,Schlicht HJ.Analysis of the earliest steps of hepadnavirus replication: genome repair after infectious entry into hepatocytes does not...
G Mottet,V Müller,L Roux - 《Journal of General Virology》 被引量: 45发表: 1999年 Replication of Sendai Virus VirusWilliamVirusS.VirusRobinsonVirusASMJ VirolBlair CD, Robinson WS. Replication of Sendai virus. II. Steps in virus assembly. J Virol. 1970 May; 5 ... Carol,D.,Blair,......
Early Steps of the Virus Replication Cycle Are Inhibited in Prostate Cancer Cells Resistant to Oncolytic Vesicular Stomatitis Virus Puckett S, Lyles DS: Early steps of the virus replication cycle are inhibited in prostate cancer cells resistant to oncolytic vesicular stomatitis virus. J... Carey,BL...
The early steps of the virus life cycle include virus attachment, receptor binding, and entry. These steps involve the initial interactions between a virus and the host cell and thus are major determinants of the tropism of the virus infection, the nature of the virus replication, and the ...
Researchers have developed a way to pull HIV out of the latent reservoir making the virus visible to the immune system and providing the potential to be killed by treatment. Part of what has made HIV infection so difficult to cure, is that once the virus enters the body, some of it hides...
HIV-1 uses cellular co-factors for virion formation and release. The virus is able to incorporate into the viral particles host cellular proteins, such as tetraspanins which could serve to facilitate HIV-1 egress. Here, we investigated the implication of
纬-Retroviruses have become adapted to recognize conserved sites that are important for the natural function of the receptor. The chapter on alpharetroviruses (e.g. avian sarcoma and leukosis virus (ASLV)) stresses a novel entry mechanism that combines aspects of both pH-independent and pH-...
Each of these mutants was also hampered in other steps in virus replication. Two mutants were defective in entry or uncoating, and the third was hampered in a step following reverse transcription. Since viral replication was analyzed under conditions in which the nuclear localization function of ...
small molecule drugs have made living with the virus manageable. Creating new small molecule drugs often takes years, which is all the more reason to start early. Some promising steps towards the goal of developing a drug that specifically targets SARS-CoV-2, the coronavirus responsible for COVI...