Furthermore, GR activation led to significant increase in the frequency of mEPSCs with larger amplitude and faster decay. Our studies indicate that differential activation of the dual receptor system of MR and GR by corticosterone targets the steps in synaptic transmission differently. The stress ...
Sakmann B (1992) Elementary steps in synaptic transmission re- vealed by currents through single ion channels. Science (Wash.) 256: 503-512.Sakmann, B. 1992. Elementary steps in synaptic transmission re- vealed by currents through single ion channels. Neuron. 8:613---629....
Elementary steps in synaptic transmission revealed by currents through single ion channels - Sakmann - 1992 () Citation Context ...ocation and properties of a single molecule at a time. Early success was achieved using ‘patch clamp’ methods, where ions passing though a single membrane-spanning...
Reception: Reception is the process of detecting a stimulus by neurons or sensory receptors present in sensory organs like skin, eyes, ear, etc. Transmission: Transmission is the process of sending signals to and fro from a neuron to another neuron or from neuron to muscles or glands Integratio...
Neurons generate and conduct these signals along their processes in order to transmit them to the target tissues. Upon stimulation, they will either be stimulated, inhibited, or modulated in some way. Learn the structure and the types of the neurons with the following study unit. Neurons ...
The alanine-serine-cysteine transporter Asc-1 regulates the synaptic availability of d-serine and glycine (the two co-agonists of the NMDA receptor) and is regarded as an important drug target. To shuttle the substrate from the extracellular space to the cytoplasm, this transporter undergoes multip...
Additionally, the plexiform layers of the retina require oxygen to maintain synaptic transmission and among retinal cells, retinal ganglion cells (RGCs) have a particularly active metabolism and are highly vulnerable to an insufficient oxygen supply. Since oxygen cannot be stored in the retina, the ...
of neural science Synaptic transmission - stepsPrinciples, Jessell
1992. Elementary steps in synaptic transmission re- vealed by currents through single ion channels. Neuron. 8:613---629.Sakmann, B. 1992. Elementary steps in synaptic transmission revealed by cur- rents through single ion channels. Neuron. 8:613-629....
The plasma membrane of a cell separates its interior from the extracellular environment and from other cells and acts both as a diffusional barrier and as an electrical insulator. This allows...Bert SakmannSpringer Berlin HeidelbergSakmann,B. (1992) Elementary steps in synaptic transmission revealed...