Synaptic transmission between dissociated adult mammalian neurons and attached synaptic boutons 来自 NCBI 喜欢 0 阅读量: 17 作者:J Drewe,G Childs,D Kunze 摘要: In most studies of synaptic currents in mammalian central neurons, preparations have been used in which synaptic currents are recorded at ...
Elementary steps in synaptic transmission revealed by currents through single ion channels - Sakmann - 1992 () Citation Context ...ocation and properties of a single molecule at a time. Early success was achieved using ‘patch clamp’ methods, where ions passing though a single membrane-spanning...
Sex-specific metabolic responses to 6 hours fasting during the active phase in young mice Night time/active phase food restriction for 6 h impaired glucose intolerance in young male and female mice. Females displayed increased capacity for lipog... T Freire,AM Senior,R Perks,... - 《Journal...
The storage of transmitter in vesicles can be blocked by inhibitors of vacuolar ATPase, such as bafilomycin A1, or of an H+-dependent transporter, such as vesamicol for acetylcholine (Parsons et al., 1993). 6. Dephosphorylation of synapsin I inhibits vesicle movements and transmission, whereas ...
synaptic transmission突触传导 synaptic同义词 adj. 突触的;(染色体)[昆]联合的 linked,joint synaptic词源中文解释 1895年,作为与 synapsis 相对应的形容词使用,源自希腊语 synaptikos,字面意思为“连接的,联合的”。 synaptic_医学行业词汇 突触的:属于突触或影响突触的 ...
SV mobilization between the two pools could be a key step for changes in synaptic efficacy. Since a variety of mutants that have distinct defects in synaptic transmission are available for detailed studies of synaptic function, this direction of approach in Drosophila seems promising. 展开 ...
by axonal stimulation (control). We subsequently broke through the presynaptic patch membrane, allowing EGTA to diffuse into the terminal for 3–5 min. Then we slowly withdrew the presynaptic pipette to reseal the terminal. With this method we could preserve synaptic transmission (e.g. ...
In addition, the effect of forskolin was blocked by catalytic and regulatory site antagonists for cAMP-dependent protein kinase (PKA), indicating a PKA-mediated mechanism. Application of 5-HT depressed the synaptic transmission and blocked Iso- and forskolin-induced potentiation. The effect of 5-HT...
Synaptic transmission and long-term potentiation are demonstrably impaired in mice 6 months of age. Evidence of gliosis and inflammation is present by at least 7 months64. Between 12 and 15 months aggregates of conformationally altered and hyperphosphorylated tau are detected in the hippocampus14,...
Blocking ChT by hemicholinium-3 inhibits all cholinergic transmission because the recycled cholinergic vesicles can no longer be refilled once this ACh precursor is exhausted. In practice, sympathetic and parasympathetic functions are more impaired when choline uptake is blocked than are motor functions...