Kadereit, By Suzanne
Through this property, striking parallels can be found between stem cells and cancer cells: tumours may often originate from the transformation of normal stem cells, similar signalling pathways may regulate self-renewal in stem cells and cancer cells, and cancer cells may include 'cancer stem cells...
曾益新院士 ：cancer stem cells or stemlike cancer cells CancerStemCellsorStem-likeCancerCellsinNPC?Yi-XinZeng SunYat-SenUniversityCancerCenter Afrequentlyaskedquestioninclinicalpractice:HowcanwepredicttheoutcomesofNPCpatients(StageII/III)without visibletumorsafterregulartherapeutics?Inotherwords:Whatcausescancer...
Cancer stem cells are rare immortal cells within a tumour that can both self-renew by dividing and give rise to many cell types that constitute the tumour, and can therefore form tumours. Such cells have been found in various types of human tumours and might be attractive targets for cancer...
Cancer stem cells (CSCs) of head and neck squamous cell carcinoma (HNSCC) are defined by high self-renewal and drug refractory potential. Involvement of Wnt/β-catenin signaling has been implicated in rapidly cycling cells such as CSCs, and inhibition of the Wnt/β-catenin pathway is a novel...
Cancer KyusonYun,BarbaraTennent, inDrug Discovery Today: Disease Models, 2007 The defining characteristics of stem cells are self-renewal and multipotentiality.Cancer stem cellshere do not refer to the stem cell of origin for a cancer; rather, they are operationally defined as cancer cells capable...
aColorectal cancer stem cells are enriched by using serum free medium based sphere culture method. Differential expressed transcriptional and translational database is established by GeneChip and proteomic analysis. Through the bioinformatic, pathologic, statistical analysis and investigation of biological ...
Cancer cell heterogeneity in tumors is caused by genetic mutation and by the existence of cancer stem cells (CSCs). CSCs are defined as a subpopulation of highly tumorigenic cancer cells with self-renewal activity. It has been reported that various types of cancer involve CSCs, and that CSCs ...
cells endowed with unique self-renewal properties and tumorigenic potential is present in some, and perhaps all, tumors. Although our understanding of the biology of these putative cancer stem cells remains rudimentary, the existence of such cells has implications for current conceptualizations of ...