The regenerative potential of pluripotent stem cells was confirmed in an animal model of Spinal Cord Injury (SCI); nevertheless, optimized growth and differentiation protocols along with reliable safety assays should be established prior to the clinical application of hESCs and iPSCs. Th e therapeutic...
In his Correspondence 'Caution urged in trial of stem cells to treat spinal-cord injury' (Nature 458,29; 2009), Yves Barde questions the wisdom of testing oligodendrocyte precursors derived from embryonic stem (ES) cells in patients, despite the promise that such cells hold for repairing these...
脊髓损伤(Spinal cord injury,SCI)会导致运动和感觉功能丧失,严重影响患者的生活质量。成年哺乳动物(包括人类)在脊髓损伤后的神经再生能力有限,从而导致永久性功能障碍。成年人中枢神经系统(CNS)再生失败的原因是外部抑制分子、神经元内在再生...
近日,戴建武研究员应邀在Stem Cells撰写题为《Direct neuronal differentiation of neural stem cells for spinal cord injury repair》的综述文章,系统总结了近年来通过功能生物材料的应用重建SCI微环境来增强NSCs神经元分化的策略以及提高NSCs固有的神经元分化能力的策略,这对SCI修复具有重要意义。 神经干细胞定向分化示意...
近日,戴建武研究员应邀在Stem Cells撰写题为《Direct neuronal differentiation of neural stem cells for spinal cord injury repair》的综述文章,系统总结了近年来通过功能生物材料的应用重建SCI微环境来增强NSCs神经元分化的策略以及提高NSCs固有的神经元分化能力的策略,这对SCI修复具有重要意义。
Spinal cord injuryTreatment of spinal cord injury has always been a challenge for clinical practitioners and scientists. The development in stem cell based therapies has brought new hopes to patients with spinal cord injuries. In the last a few decades, a variety of stem cells have been used ...
Stem cell treatment for the spinal cord injury – A concise reviewdoi:10.1016/j.ijnt.2014.05.008Spinal cord injuryStem cellsBone marrowBone marrow derived stem cellsMesenchymal stem cellsAbstract A spinal cord injury (SCI) is any injury of the spinal cord caused due to trauma and mostly ...
Traumatic spinal cord injury (SCI) results in direct and indirect damage to neural tissues, which results in motor and sensory dysfunction, dystonia, and pathological reflex that ultimately lead to paraplegia or tetraplegia. A loss of cells, axon regeneration failure, and time-sensitive ...
Stem cell therapy has the potential to provide a valuable treatment approach for spinal cord injury, but no consensus yet exists regarding which type of stem cell is likely to be most effective in the clinical setting. In this article, Sahni and Kessler
Stem cells are considered promising agents for the recovery of spinal cord injuries. European scientists explore their abilities and plan future therapeutic strategies.