Genetically engineered mesenchymal stem cells have demonstrated great promise as potential cancer therapies targeting gastrointestinal malignancies including pancreatic, gastric, colorectal, and hepatocellular carcinomas and may achieve tumor selectivity over normal tissues by three complementary mechanisms.Emily ...
Introduction The cancer stem cell model for tumor progression is the first model of its type to suggest that only one subpopulation of cancer cells is capable of proliferating indefinitely. These cells resemble normal stem cells in their capacity for self-renewal and multi-potential differentiation, ...
Cancer Stem Cells Cancer Immunotherapy Cancer Biomarker The discovery of cancer stem cells (CSC) in certain tumor types launched a new discipline within cancer research. Many scientists are now looking to identify and characterize populations of tumor cells which have acquired stem cell–like properti...
2024年4月24日,来自美国希望之城国家医疗中心血液学与造血细胞移植科的Jianhua Yu与Michael A. Caligiuri共同在Cell Stem Cell期刊发表题为Human anti-PSCA CAR macrophages possess potent antitumor activity against pancreatic cancer(人类抗PS...
Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.
關於“癌症幹細胞(cancer stem cells)”這觀念,如今依舊是討論非常熱烈,姑且不論其實質是否是正確的理論,但這概念在臨床或是研究的應用上卻非常有用,另一方面,癌症幹細胞的定義也隨者時間不段地調整。 Malignant cell populations are organized as unidirectional cellular hierarchies ...
B. Jr . Multipotentiality of single embryonal carcinoma cells. Cancer Res. 24, 1544–1551 (1964). CAS PubMed Google Scholar Pierce, G. B. & Speers, W. C. Tumors as caricatures of the process of tissue renewal: prospects for therapy by directing differentiation. Cancer Res. 48, 1996...
[8] Jarno,Drost, Richard H ,et al.Sequential cancer mutations in cultured human intestinal stem cells.[J].Nature, 2015. [9] Matano M , Date S , Shimokawa M ,et al.Modeling colorectal cancer using CRISPR-Cas9-mediated engineering of human intestinal organoids[J].Nature Medicine, 2015, 21...
stem cells are rare immortal cells within a tumour that can both self-renew by dividing and give rise to many cell types that constitute the tumour, and can therefore form tumours. Such cells have been found in various types of human tumours and might be attractive targets for cancer ...
2024年5月15日,来自德国图宾根大学生物医学工程系的Peter Loskill和维尔茨堡大学医学院的Miriam Alb研究团队合作在Cell Stem Cell杂志上发表题为Breast cancer-on-chip for patient-specific efficacy and safety testing of CAR-T cells的研...