5 Department of Pharmacology, Arizona College of Osteopathic Medicine, Midwestern University, 19555 North 59th Avenue, Glendale, AZ 85308, USA Corresponding author Ting Xie Summary It is widely postulated that tissue aging could be, at least partially, caused by reduction of stem cell number, activi...
DNA damage response DDR Drosophila intestinal stem cell ISC mouse embryonic stem cell mESC mouse embryonic fibroblast MEF Introduction Turnover of the intestinal epithelium occurs approximately weekly and is controlled by the tight balance of self-renewal and differentiation of stem cells. This balance ...