Statins are the most popular and effective lipid-lowering medications beneficial in hypercholesterolemias and prevention of cardiovascular diseases. Growing evidence supports theory that statins exhibit neuroprotective action in acute stroke, Alzheimer's disease, Parkinson's disease, multiple sclerosis or ...
Statins are classified into two groups based on their lipophilicity: lipophilic statins, which include atorvastatin, simvastatin, pitavastatin, and cerivastatin and hydrophilic statins, which include rosuvastatin and pravastatin (Wood et al.2014). Statins function primarily by competitively and selectively ...
Thus, the effects we describe are to the most part attributable to simvastatin treatment. Although it is often assumed, and some indications exist, that lipophilic statins more easily cross over into the brain to affect neuronal function12,13,14, it is currently unclear if different types of ...
associations of hydrophilic statins with prostate cancer-specific mortality were supported by a large registry analysis of patients with advanced prostate cancer following ADT that showed somewhat more pronounced associations among users of hydrophilic statins, compared to users of lipophilic statins [43]....
while lipophilic statins were found to be associated with lower breast cancer-specific and all-cause mortality, the protective effect of hydrophilic statins on these outcomes was weak, suggesting that the protective effects of statins on breast cancer are affected by the type of statin [64]. Howev...
while lipophilic statins were found to be associated with lower breast cancer-specific and all-cause mortality, the protective effect of hydrophilic statins on these outcomes was weak, suggesting that the protective effects of statins on breast cancer are affected by the type of statin [64]. Howev...
That's in contrast to hydrophilic statins — like rosuvastatin (Crestor) and pravastatin (Pravachol) — which act mainly in the liver. In this study,there was no link between those statins and increased dementia risk. The findings do not prove that lipophilic statins directly raise dementia risk...
These findings highlight the differential effects induced by ABL allosteric versus ATP-competitive inhibitors, and they support the notion that ABL allosteric inhibitors preferentially sensitize lung cancer cells to cell death in vitro by combination treatment with lipophilic statins. There are conflicting ...
Lipophilic statins suppress cytotoxicity by freshly isolated natural killer cells through modulation of granule exocytosis. Int Immunol 2007; 19: 163–173. Article CAS PubMed Google Scholar Dirks AJ, Jones KM . Statin-induced apoptosis and skeletal myopathy. Am J Physiol Cell Physiol 2006; 291: ...
Our results suggest that the lipophilic statins used in this study have the capacity to inhibit ZIKVin vitro. However, our results do not necessarily mean that the hydrophilic statins are not capable of inhibiting ZIKV infection. Lipophilic statins readily enter cells through passive transport, while...