Lipohilic statins impair the viability of primary hATF in culture by induction of intrinsic apoptotic pathways whereas hydrophilic statins do not affect hATF viability. This could be due to the hydrophilic characteristic of the molecule, preve
We investigated effects of chemically different statins on RhoA kinase inhibition in cardiac myocytes (CM). Neonatal mouse CM were treated with simvastatin, pitavastatin, atorvastatin, rosuvastatin, or pravastatin and compared to vehicle. After 48hs only lipophilic and not hydrophilic statins, induced ...
Statins have beneficial effects on cardiovascular diseases. However, it is unclear which type of statins, hydrophilic statin (Hydro-stadoi:10.1016/S0735-1097(12)60276-9Ryu ShuttaMasami NishinoAyano IshiyamaNaotaka OkamotoIssei KomuroElsevier BVJournal of the American College of Cardiology...
INTRODUCTION: Some available experimental studies have reported that hydrophilic statins might have advantages compared with lipophilic statins in patients with coronary artery disease (CAD). Therefore, we performed a meta-analysis of randomized controlled trials (RCTs) investigating the potential differences...
Background: Statins reduce the incidence of cardiovascular events, but no randomized trial has investigated the best statins for secondary prevention. We compared the efficacy of hydrophilic pravastatin with that of lipophilic atorvastatin in patients with acute myocardial infarction (AMI).Izawa, Atsushi...
Hydrophilic statins (pravastatin, rosuvastatin) may cause less muscular events than lipophilic statins (e.g. simvastatin, atorvastatin) due to lower passive diffusion into muscle cells. Objective To compare the risk of muscular events between statins at comparable lipid-lowering doses and to evaluate ...
Lipophilic vs. hydrophilic statins and psychiatric hospitalizations and emergency room visits in US Veterans with schizophrenia and bipolar disorderdoi:10.1515/PTERIDINES-2020-0028Teodor T. PostolacheDeborah R. MedoffClayton H. BrownLi Juan Fang
We tested whether two different types of statins, hydrophilic pravastatin and lipophilic simvastatin, attenuated neurological injury following CA/CPR. The efficacy of pravastatin and simvastatin combination treatment was also assessed. Methods Isoflurane-anesthetized adult male wild-type C57Bl/6 mice ...
Hydrophilic statins showed a significantly higher risk of MACE and UA compared to lipophilic statins (RR 1.11 [95% CI 1.02, 1.21] and 1.30 [95% CI 1.04, 1.62]), but subgroup analysis showed a lack of significant difference betwe...
Differential Prognostic Effect of Lipophilic Versus Hydrophilic Statins in Heart Failure Patients: A Meta-Analysis of Randomized Controlled TrialsBackground: Nearly half of patients with heart failure (HF) have preserved ejection fraction (EF) and the mortality of patients with HF with preserved EF (...