So when observational studies show a link between statin use and dementia, you always have to ask: Is this a true causal link or is it simply that people prescribed statins tend to be older, and older patients are more likely to get dementia? Teasing out such distinctions is never easy an...
Dementiaa 27 (0.4) 29 (0.4) .8 Chronic obstructive lung diseasea 853 (12.2) 842 (12.1) .8Rheumatologic diseasesa 159 (2.3) 153 (2.2) .8Peptic ulcer diseasea 101 (1.4) 101 (1.4) >.99Mild liver diseasea 30 (0.4) 27 (0.4) .8 ...
Lipid Management Clinical Practice Guidelines (CFP-MFC, 2023) news Lipids and Dementia: A Complex and Evolving Story news Low Lipids Linked to Thyroid Cancer Recurrence news The Management of Anxiety in Primary Care news Six Updates on Stroke Management Related Conditions & Procedures Lipid ...
Differential rates of conversion to dementia were assessed with Kaplan-Meier statistics, and a Cox multivariable model controlled for all identified factors with univariate hazard ratios with p<0.10 significance. Statistical parametric mapping (spm) was used to measure the extent of gray matter (2mm)...
treated with statins. In general, the patients who were treated with statins had slightly higher values in the cognitive tests carried out, even though they were more likely to have diagnoses such ashigh blood pressure, cardiovascular disease and diabetes, all of which arerisk factorsfor dementia...
These findings are consistent with those from a recent systematic review of randomized trials and observational studies that found no adverse associations of statins with incidence of Alzheimer disease, dementia, or decreased scores on tests of cognitive performance.52 No trial directly compared treatment...
Zika virus (ZIKV) is a mosquito-borne member of the Flaviviridae family. ZIKV infection has been associated with neurological complications such as microcephaly in newborns and Guillain-Barré syndrome in adults; thus, therapeutic agents are urgently nee
Objective: To explore the association between the use of lipid-lowering medications and cognitive decline over time in a cohort of patients with AD or mixed dementia with indication for lipid-lowering treatment. Methods: A longitudinal cohort study using the Swedish Registry for Cognitive/Dementia ...
Screening is really important because we can intervene early with both patient and family. What are we looking for at such an early age? It's those heterozygous familial hyperlipidemia syndromes, which have a prevalence of 1 in 250 kids and is not related toobesity. So we should be really ...
do statins have "pleiotropic" benefits in addition to their principal action of inhibiting 2-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme in cholesterol biosynthesis? Three reports at the American Heart Association (AHA) 2008 Scientific Sessions in New Orleans, Louisiana, ...