Prostate cancer cases were identified by linkage to the KP California Cancer Registries. Statin exposure, estimated from automated KP outpatient pharmacy records (available since 1991 in Southern California and since 1994 in Northern California), was treated as time-varying and defined as the ...
The linear trapezoidal rule was used to calculate the area under each drug concentration‒time curve (AUC0–τ, µg h/L) from dosing to the end of the dosing interval (τ = 24 h). The apparent oral clearance (Cl/F) was calculated from the dose/AUC0–τ. Student’s t‐test...
34 A case-crossover analysis is subject to intraindividual confounding, for example, if what brings them to treatment now instead of earlier is linked in some way to memory loss. Confounding by time-varying indication should be less of a problem for statins than for drugs used for acute ...
Design, Setting, and Participants A microsimulation model was designed to estimate life expectancy, quality of life, costs, and health outcomes over a lifetime horizon. African American–specific data from 472 participants in the Jackson Heart Study (JHS) at intermediate risk for atherosclerotic cardi...
Statins are among the most frequently issued drugs that patients usually need to take for a lifetime. They are often an integral part of a polytherapeutic approach in preventing and treating cardiovascular diseases. As such, they might often interact with drugs prescribed for treatingacute and ...
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Questionnaire asked participants to report whether they had taken any cholesterol-lowering drugs regularly during the past year. Time zero was defined as the point at which patients began to take statins or, if never on statins, the date of the first recorded low- density lipoprotein or total ...
While this residue was not identified within the statin-treated cells, its absence is likely due to the reduced efficiency of the protocol, the labile nature of the modification, and the longer prep time associated with collecting protein from cells. The final HMGylated residue identified was ...
The log-rank test was used to compare time to LDL cholesterol control between patients who initially accepted statin therapy vs patients who did not accept statin therapy. A marginal Cox proportional hazards regression model was used to estimate the association between statin therapy acceptance vs ...
Healthy RBCs can be seen to collide with the circular pillars, and almost recover their initial shape in <0.5 s whereas statin-treated cells take more time to return to their original size. Interestingly, a-RBCs take the longest time to recover, and the final cell size is the least recover...