Question What is the time to benefit of statin therapy for primary prevention of cardiovascular events in adults aged 50 to 75 years? Findings In this survival meta-analysis of 8 trials randomizing 65 383 adults, 2.5 (95% CI, 1.7-3.4) years were needed to avoid 1 cardiovascular event fo...
Preventive interventions should be offered only to patients whose life expectancy exceeds that of the intervention s time to benefit - if that time interval is known. In this metaanalysis, researchers determined the time to benefit after starting statins for preventing a first major adverse cardiovasc...
Acute coronary syndrome (ACS) is associated with a number of abnormalities in inflammation, endothelial function, and coagulation, all of which appear to be modulated by statins. We examined the time to benefit of different statin regimens in the Pravastatin or Atorvastatin Evaluation and Infection ...
Estimated individual lifetime benefit from PCSK9 inhibition in statin-treated patients with coronary artery diseaseObjective In statin-treated patients with stable cdoi:10.1136/HEARTJNL-2017-312510Lotte KaasenbroodKausik K RayS Matthijs Boekholdt
Weight Gain at the Time of Menopause Early and Sustained Survival Benefit Associated With Statin Therapy at the Time of Percutaneous Coronary Intervention Ovarian conservation at the time of hysterectomy and long-term health outcomes in the nurses' health study....
The case-control approach used in the published study yielded a rate ratio of lung cancer incidence of 0.62 with statin use (95% confidence interval = 0.55-0.71). A case-control approach that properly accounts for time produces a rate ratio of 0.99 (0.85-1.16)-suggesting no benefit of ...
Similarly, participants who develop new conditions during follow-up will also benefit from early diagnosis and linkage to care. In addition, spinal TB patients will be monitored closely by the study team throughout the study period.Availability of data and materials Not applicable.Abbreviations AE: ...
A major challenge in the domain of healthcare is ascertaining whether a given treatment influences or determines an outcome—for instance, whether there is a survival benefit to prescribing a certain medication, such as the ability of a statin to lower the risk of cardiovascular disease. ...
lipoproteins may provide additional information in risk stratification.(1) In particular, persistently elevated measures of low-density lipoprotein (LDL) particles, in patients whose LDL-cholesterol (C) appears optimally controlled, may identify individuals more likely to benefit from more intensive lipid...
Interestingly, a subsequent evaluation in the SCOT-HEART study showed an even greater benefit of coronary CTA in patients qualifying for noninvasive testing under the NICE guidelines, with less benefit in those with nonanginal symptoms—who probably should probably not receive any further noninvasive...