Any of a class of lipid-lowering drugs that reduce serum cholesterol levels by inhibiting a key enzyme involved in the biosynthesis of cholesterol. [From the names of such lipid-lowering drugs aspravastatin.] American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 20...
andahighlevelofLDLcholesterol(LDLC)inbloodisariskeventreports(AERs)submittedtotheUSFoodandDrug factorforCVD[15].GiventhatareductioninLDLCresultsinAdministration(FDA).Thisdatabasereliesonreportsof thepreventionofCVD,theinhibitorsof3hydroxy3methylgluspontaneousadverseeventstotheFDAgeneratedbyhealth tarylcoenzymeA(...
The meaning of STATIN is any of a group of drugs (such as lovastatin and simvastatin) that inhibit the synthesis of cholesterol and promote the production of LDL-binding receptors in the liver resulting in a usually marked decrease in the level of LDL an
Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: results of AFCAPS/TexCAPS. JAMA. 1998;279(20):1615-1622. doi:10.1001/jama.279.20.1615ArticlePubMedGoogle ScholarCrossref 18. Furberg C; ALLHAT Officers and Coordinators for the...
For more information, ask your healthcare provider or pharmacist. Talking to your doctor? NEXLIZET is pronounced “NEX-lee-zet” See What NEXLIZET Can Do What are NEXLIZET and NEXLETOL? Along with a diet: NEXLETOL is used, with other cholesterol-lowering medicines, or alone when use with...
For more information, ask your healthcare provider or pharmacist. Talking to your doctor? NEXLETOL is pronounced “NEX-le-tol” See What NEXLETOL Can Do What are NEXLIZET and NEXLETOL? Along with a diet: NEXLETOL is used, with other cholesterol-lowering medicines, or alone when use ...
The most popular one is known by two different names, either “mevinolin” or “monacolin K” and this particular fungal compound supports healthy cholesterol levels by blocking the action of HMG-CoA reductase enzyme in your liver. Years ago, one drug company saw green when they learned about...
Medicine Any of a group of drugs which act to reduce levels of cholesterol in the blood. Origin: 1980s: from stat- as in -stat + -in. -stat: Denoting instruments, substances, etc. maintaining a controlled state: -in: (Chemistry) Forming names of organic compounds, pharmaceutical produc...
Those who initiated a statin were more likely to have diagnostic codes for hyperlipidemia, hypertension, and diabetes. They were also more likely to have arthritis; polypharmacy; use diuretics, angiotensin-converting enzyme inhibitors, β-blockers, and take nonstatin cholesterol-lowering medications; ...
Muscle cells possess a similar repertoire for cholesterol biosynthesis as liver We next asked how the muscle was equipped to synthesize and metabolize cholesterol. We found key enzymes for cholesterol biosynthesis (hydroxymethylglutaryl-Coenzym A-synthase HMGCS1, HMGCR, CYP51A1, 7-dehydrocholesterol redu...