Despite discontinuing atorvastatin, his CPK remained persistently elevated. Muscle biopsy was consistent with necrotizing myopathy. Anti-HMG CoA reductase antibody was strongly positive. Steroids followed by intravenous immunoglobulin were given. The patient’s muscle weakness, CPK, and liver functions ...
Taking into account that PUFA mainly works on TG levels with a relatively small effect on LDL-C, they should be mainly considered for statin-intolerant patients with obesity, diabetes (insulin resistance), or metabolic syndrome in whom elevated LDL-C is accompanied by high levels of TGs (athero...
childhood myopathy cases characterized by relatively mild muscle weakness, slowly progressing course, mildly elevated creatine phosphokinase (CPK), and contracture... JM Hunter,ME Ahearn,CD Balak,... - 《Molecular Genetics & Genomic Medicine》 被引量: 24发表: 2015年 THU0192 Myositis in primary sj...
While the patient was on steroids, her muscle weakness and CPK level gradually improved. She was discharged on oral steroids.Statin-induced autoimmune myopathy should be considered with high suspicion when there is a significantly elevated CPK level. Discontinuation of statin therapy does not lead to...
Statins also carry warnings that memory loss, mental confusion, high blood sugar, and type 2 diabetes are possible side effects. Myositis, inflammation of the muscles. Rhabdomyolysis, extreme muscle inflammation and damage. Elevated levels of CPK, or creatine kinase, a muscle enzyme that when elev...
The incidence of adverse events with all doses of atorvastatin was 12.1%.Adverse events were asthenia (1.6%), myalgia (1.4%), constipation (1.1%), dyspepsia (1.1%), elevated AST/ALT 3 times upper limit, regardless of causality (1.2%), and one case of elevated CPK 10 times the upper ...
SINAM should be suspected in any patient on a statin, regardless of duration of treatment, who presents with proximal muscle weakness and a markedly elevated CPK, often > 1000. Treatment, like other forms of autoimmune myopathies, is often centered around immunomodulatory therapies such as high ...
Treatment was transitioned to low doses of prednisone and infrequent IVIg dosing. Approximately 10 years after initial presentation she experienced increasing difficulty standing up straight, resulting in camptocormia. CPK was again elevated in the 500鈥 1000 range. MRI of the thoracic spine and ...
Here, we presenta case of a 42-year-old woman diagnosed with SINM and was found to have persistently elevated CPK despite discontinuation of statins. Our case also suggests that intravenous (IV) immunoglobins and steroids are an effective and well-tolerated alternative to immunosuppressants....
A 58-year-old diabetic and hypertensive female presented with pain and weakness of lower limbs, difficulty in walking, shortness of breath, and decreased urine output. She was receiving statin therapy for the past 1 week. Her blood investigations showed elevated creatine phosphokinase (CPK) and ...