We defined a detailed clinical and laboratory phenotype of a cohort of patients referred to the lipid clinic of a governmental health maintenance organization for statin intolerance attributable to muscle pain without CPK elevation (myalgia) and characterized their response to alternative lipid-lowering ...
Statins are prescribed for prevention and treatment of coronary artery disease. Statins have different cholesterol lowering abilities, with rosuvastatin and atorvastatin being the most effective, while statins like simvastatin and fluvastatin having lowe
Berberine and silymarin IIb B 102 dyslipidemic patients 500 mg berberine, 105 mg silymarin 3 months −32.2% (p < 0.05) ↓ TC −23.2% (105) Safety biochemical measurements included transaminases (AST and ALT), g-GT, and CPK. Soy protein and plant sterol IIa B 24 dyslipidemic and MetS...
Less than 1% had an aspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) elevation greater than 3 times upper limits of normal and there were no documented cases of creatine phospho- kinase (CPK) elevation greater than 10 times upper limits of normal. Two trials were designed ...
Myalgia,rhabdomyolysisandincreaseofcreatinephosphokinase(CPK)levelwerecodedasPPandPrespectively. :10.1371/journal.pone.0028124.t001 emicpatientsreceivinghighdosesofstatins,indicatedthattheelevationincreatinephosphokinaselevel,theconditionisknown symptomswerereportedby10.5%ofpatients[3,26].Inarecentlyasmyositis[4],but...
upper limit of normal.ResultsOf 3042 patients reviewed, 128 (4.2%) were identified as having daptomycin-associated myopathy, 25 (0.8%) of whom had rhabdomyolysis; 121 (95%) of the 128 were adults, and the mean duration of therapy before CPK elevation was 16.7 days (range, 1-58 days). ...
In addition the presence of final TIMI III flow, TIMI blush grade, CPK peak, stent thrombosis and death from any cause during follow-up were evaluated. The data were combined as relative risk (RR) or difference of means (DM) with their 95% confidence interval (CI), using RevMan software...
Rhabdomyolysis is characterized by elevation of plasma creatine phosphokinase (CPK) level, and multiple organ disorders, especially renal failure, as well as approximately 50% of acquired rhabdomyolysis are caused by pharmaceuticals. Statins are known to cause rhabdomyolysis, and its incidence is >= 10...
Empty CellStatin-Associated Muscle Symptoms With or Without CK ElevationSelf-Limited Toxic MyopathySINAM Symptoms No muscle weaknessMyalgia (++) Proximal muscle weakness (++)Myalgia (+) Proximal muscle weakness (+++)Myalgia (++)Dysphagia (+/++)Respiratory failure (+/-) CPK <1,000 IU/l <20,...
Severe cases with functional impairment or significant elevation of CK levels are uncommon. However, it is crucial to confirm the involvement of statin treatment and exclude any other potential causes of muscle pain, including those related to other medications. Analyzing co-prescriptions and ...