An investigation of the effect of glucagon on liver high energy phosphate concentration during a low flow state is presented. Two groups of dogs were subjected to a 120 minute period of hemorrhagic hypotension followed by re-infusion of shed blood plus additional normal saline to restore the ...
Hvistendahl MK, Naimi RM, Enevoldsen LH, Madsen JL, Fuglsang S, Jeppesen PB (2020) Effect of glepaglutide, a long-acting glucagon-like peptide-2 analog, on gastrointestinal transit time and motility in patients with short bowel syndrome: findings from a randomized trial. JPEN J Parenter Ente...
We confirmed that the TWEAK/Fn14 pathway is dysregulated in the skeletal muscle of SOD1G93A mice. We then showed that Fn14-depleted SOD1G93A mice had an increased lifespan and decreased muscle pathology, which was dependent on exposure to exercise and sex. Our study provides further insights...
but in the range of 19–25 nucleotides siRNAs show similar efficiency in gene silencing [25]. The use of short siRNA is preferred because longer siRNAs can provoke an inflammatory antiviral immune response [26]. Currently, however, the introduction of...
1 Glucagon-like-peptide-1 receptor agonists (GLP-1RA) have recently garnered increased media attention and research interest due to their weight loss properties and utilization as an effective T2DM treatment. 4 Their mechanism of action for T2DM and weight loss involves stimulating insulin secretion ...
Glucagon-like peptide-1 promotes satiety and suppresses energy intake in humans Journal of Clinical Investigation, 101 (1998), pp. 515-520 View in ScopusGoogle Scholar [13] J. Eng, W.A. Kleinman, L. Singh, G. Singh, J.P. Raufman Isolation and characterization of exendin-4, an exendin...
Na+ is maintained at a very low intracellular concentration by a basolateral Na+/potassium (K+)-adenosine triphosphatase (ATPase), an energy-dependent pump that pumps K+ into the cell and Na+ out of the cell. Glucose leaves the cell down its concentration gradient into the blood through ...
Thus, maleimide reagents have been extensively investigated for the bioconjugation of proteins, peptides, antibodies, and other bioactive molecules to polymers and other ligands via maleimide-thiol addition reaction. 52,53,−54 We have an amine group containing maleimide reagent (1 H-pyrrole-1-...
Frampton J et al (2021) The effect of a single bout of continuous aerobic exercise on glucose, insulin and glucagon concentrations compared to resting conditions in healthy adults: s systematic review, meta-analysis and meta-regression. Sports Med 51:1949–1966. https://doi.org/10.1007/s40279...
Overview of GLP-1 receptor agonists Further understanding of the gut-brain axis has shed light on the crucial endocrine hormones glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), and GLP-2, prompting enthusiastic development of a new generation of effective, hormo...