Herein we present a novel, long-acting glucagon analogue (GCG104) with high receptor-specificity and potent in vivo action. It has allowed us to make two important observations about the biology of sustained GCGR agonism. First, it causes weight loss in mice by direct receptor signalling at ...
The action of glucagon is to raise the level of blood glucose, in contrast to the action of insulin that is to lower blood glucose. Glucagon acts on the liver cell to cause the breakdown of glycogen to release free glucose into the bloodstream. It accomplishes this by binding to and activ...
Insulin is a physiological inhibitor of glucagon release and function; however, it is incompletely understood at the molecular level how insulin exerts its effects on glucagon action (1). The relationship between insulin and glucagon signaling is more complex than a stochastic “on/off” switch, ...
The primary glucagon function or glucagon action is to raise blood glucose levels by: Prompting the liver to increase glucose production Causing the liver to decrease glucose consumption Initiating the release of glucose from glycogen, a sugar storage molecule primarily in the liver and skeletal ...
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J. Biology of incretins: GLP-1 and GIP. Gastroenterology 132, 2131–2157 (2007). Article CAS PubMed Google Scholar Campbell, J. E. & Drucker, D. J. Pharmacology physiology and mechanisms of incretin hormone action. Cell Metab. 17, 819–837 (2013). Article CAS PubMed Google Scholar ...
Glucagon is a 29-amino acid pancreatic hormone that maintains euglycemia during fasting through action on the liver. It drives gluconeogenesis and glycogenolysis and, in this capacity, can act as a counter-regulatory hor- mone to insulin1. However, the biology of glucagon is more complex ...
Whereas glucagon has major effects on glucose mobilization from liver, the action of glucagon-like peptide 1 is restricted to pancreatic islet B-cells where it promotes insulin secretion in response to a glucose stimulus. Glucagon-like peptide 1 may be useful for modulating insulin secretion. ...
While previous studies have characterized regulatory components transducing linear Akh signaling promoting carbohydrate production, the spatial elucidation of Akh action at the organelle level still remains largely unclear. In this study, we find that Akh phosphorylates extracellular signal-regulated kinase (...
Action Closing Prosecution in Inter Partes Reexam 95/000,276, dated Mar. 17, 2011 (25 pages). Adelhorst et al., “Structure-activity studies of glucagon-like peptide-1,” J Biol Chem 269(9):6275-6278 (1994). Ali et al., “Cardiomyocyte glucagon receptor signaling modulates outcomes ...