Firstly, when the CRPC cell lines C4-2 and CWR22Rv1 were induced by hypoxia, the expression of the UL16 binding protein (ULBP) ligand family of natural killer (NK) group 2D (NKG2D; ULBP-1, ULBP-2 and ULBP-3) and MHC class I chain-related proteins A and B (MICA/MICB) ...
在PDOs中,治疗后观察到Ki67表达降低。在3个独立的CRC患者中,研究者发现肿瘤细胞内高JAK/STAT3表达与高基质侵袭(TSPhigh)患者癌症特异性生存率降低之间存在高度显著的关联。TSPhigh组中具有高磷酸化STAT3 (pSTAT3)的患者具有更高的CD66b +细胞内流和更高的肿瘤PDL1表达。全切片肿瘤的大量RNAseq表现为NFκB信号的富...
[1]. Tang J, Yu JX, Hubbard-Lucey VM, Neftelinov ST, Hodge JP, Lin Y. Trial watch: The clinical trial landscape for PD1/PDL1 immune checkpoint inhibitors. Nat Rev Drug Discov. 2018;17(12):854-855. doi:10....
在PDOs中,治疗后观察到Ki67表达降低。在3个独立的CRC患者中,研究者发现肿瘤细胞内高JAK/STAT3表达与高基质侵袭(TSPhigh)患者癌症特异性生存率降低之间存在高度显著的关联。TSPhigh组中具有高磷酸化STAT3 (pSTAT3)的患者具有更高的CD66b +细胞内流和更高的肿瘤PDL1表达。全切片肿瘤的大量RNAseq表现为NFκB信号的富...
(scRNASeq) analysis using murine surrogate drugs at three timepoints (following one (1W), two (2W), or three (3W) weeks of mouse surrogate STAT3 ASO, vehicle, or control ASO treatment alone, or anti-PDL1 alone or combined with STAT3 ASO (combo) in W2 and W3) in Balb/c mice ...
HCC-CAF-primed neutrophils impaired T-cell function through the PD1/PDL1 signaling pathway. We revealed that HCC-CAFs induced the activation of STAT3 pathways in neutrophils, which are essential for the survival and function of activated neutrophils. In addition, we demonstrated that HCC-CAF-...
according to RNA-Seq analysis. Their findings therefore demonstrate that LOC339059 functions as a tumor suppressor by competitively inhibiting c-Myc, which reduces macrophage M2 polarization and IL-6/STAT3-signaling-mediated PDL1 expression [105]]. It has been shown that lncARSR functions as the si...
Our previous study showed that metformin inhibits the proliferation of lung cancer cells and exerts anti-tumor effects in an AMPK-C/EBPβ-PDL1 signaling-dependent manner [45]. In our study, both single-cell data and in vitro experiments revealed that C/EBPβ can regulate IL-6 expression, ...
Cancer-associated fibroblasts induce PDL1+ neutrophils through the IL6-STAT3 pathway that foster immune suppression in hepatocellular carcinoma. Cell Death Dis. 2018;9:422. 126. Li S, Cong X, Gao H, Lan X, Li Z, Wang W, et al. Tumor-associated neutrophils induce EMT by IL-17a to ...
Besides, silencing of miR-155-5p could initiate the PD1/PDL1 pathway-mediated macrophage M2 polarization and inhibit ITP progression by up-regulating SOCS1 (Chang et al., 2020). Given this background we examined differences in the proportion of M2 phenotype macrophages in ITP patients and ...