A role for STAT3 and cathepsin S in IL-10 down-regulation of IFN-gamma-induced MHC class II molecule on primary human blood macrophages. J Leukoc Biol. 2010; 88 :303–311. doi: 10.1189/jlb.1009659. [ Cross Ref ]Chan LLY, Cheung BKW, Li JCB, Lau ASY: A role for STAT3 and ...
Phosphorylation of Stat3 at Ser727 via MAPK or mTOR pathways is required for optimal transcriptional activation in response to growth factors and cytokines including IFN-gamma and ciliary neurotrophic factor (CNTF) (4,5). Jak/Stat pathways also play important roles in oncogenesis, tumor progression...
STAT3 has been shown to be activated by IFN-alpha but not IFN-beta. The transcription factors associated with STAT3 are c-Jun and cyclic AMP-responsive enhancer binding protein (CREB). STAT3 mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key ...
Introduction Host responses to pathogens are ordered, time-dependent, and tissue-compartmentalized, coordinated by the release of soluble factors, such as growth factors and inflammatory cytokines, which engage, activate, and regulate innate immune cells [1]. Since the magnitude of the immune response...
CXC chemokine ligand 9/monokine induced by IFN-gamma production by tumor cells is critical for T cell-mediated suppression of cutaneous tumors. J Immunol. 2007;178(4):2278–86. Article CAS PubMed Google Scholar House IG, Savas P, Lai J, et al. Macrophage-Derived CXCL9 and CXCL10 Are ...
A role for STAT3 and cathepsin S in IL-10 down-regulation of IFN-gamma-induced MHC class II molecule on primary human blood macrophages. J. Leukoc. Biol. 2010, 88, 303-311. [CrossRef] [PubMed]Chan LL, Cheung BK, Li JC, Lau AS. A role for STAT3 and cathepsin S in IL-10 down...
IFN gamma 抗体IFN gamma 抗体:偶联ATTO 390IFN gamma 抗体:偶联ATTO 488IFN gamma 抗体:偶联ATTO 565IFN gamma 抗体:偶联ATTO 594IFN gamma 抗体:偶联ATTO 633IFN gamma 抗体:偶联ATTO 655IFN gamma 抗体:偶联ATTO 680IFN gamma 抗体:偶联ATTO 700IFN gamma 抗体:偶联碱性磷酸酶IFN gamma 抗体:偶联APCIFN ...
Tumor-associated neutrophil cells are also one of the most infiltrating immune cells within the tumors. High expression of STAT3 in neutrophils attenuates their tumor-killing activities [123]. Since IFN-β suppresses the activity of STAT3, IFN-β–deficient mice display more neutrophils with higher ...
We also found that Rac1 deficiency led to attenuation of IFN-gamma-responsive transcriptional responses. Compared with levels in control cells, IFN-gamma-induced IFN-gamma-activated sequence promoter activity was markedly reduced in both C6 astroglioma cells and primary astrocytes expressing RacN17, ...
Unique CD14 intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23/IFN-gamma axis. J Clin Invest. 2008;118(6):2269–80. CAS PubMed PubMed Central Google Scholar Wortzel I, Dror S, Kenific CM, Lyden D. Exosome-mediated metastasis: communication from a distance. ...