专利摘要:本发明涉及Star‑PAP在制备提高脂肪胰岛素敏感性药物中的应用。本发明通过实验发现了PAP介导的RNA多聚腺苷酸化在脂肪代谢稳态的作用,Star‑PAP作为InsrRNA结合蛋白,其缺乏可以导致脂肪萎缩症和胰岛素抵抗,为下一步制备提高脂肪胰岛素敏感性药物奠定了基础。 专利权项:1.Star-PAP在制备提高脂肪胰岛素敏感性药...
Li W, Anderson RA. Star-PAP controls HPV E6 regulation of p53 and sensitizes cells to VP-16. Oncogene. 2014;33:928-32.Li W,Anderson R A.Star-PAP controls HPV E6regulation of p53and sensitizes cells to VP-16.Oncegene. 2013Li W, Anderson RA. 2014. Star-PAP controls HPV E6 ...
A phosphoinositide-modulated nuclear PAP, Star-PAP, was then reported to regulate a select set of mRNAs in the cell. In addition, several non-canonical PAPs have been identified with diverse cellular functions. Further, canonical PAP itself exists in multiple isoforms thus illustrating the diversity...
Poly(A)polymerase(PAP);CanonicalPAP;PAPisoforms;PAPα;Star-PAP;PI4,5P 2 ;PIPKIα; CKI;Polyadenylation;Uridylation;3′-endprocessing;Oxidativestress 1Introduction Ineukaryotes,nuclearmRNAsynthesisisamultistepprocessthatbeginswithtranscription andendswithprocessingatthe3′-UTR[1–5].ThevariousstepsofmRNAsynt...
Here, we employ HITS-CLIP to map the cellular Star-PAP binding landscape and the mechanism of global Star-PAP mRNA association. We show a transcriptome-wide association of Star-PAP that is diminished on Star-PAP depletion. Consistent with its role in the 3′-UTR processing, we observed a ...
Starpap . Paper Recycling Company in Poland,Swietokrzyskie,Starachowice, , ul. Rogowskiego 15 27-200. Waste Recycling Company
Star-PAP is a recently identified nuclear speckle localized non-canonical poly(A) polymerase that has a functional interaction with PIPKIα, and whose activity is modulated by the PIPKIα product, PI4,5P 2. Similar to other poly(A) polym... DL Mellman,RA Anderson - PubMed 被引量: 30发表...
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