专利摘要:本发明涉及Star‑PAP在制备提高脂肪胰岛素敏感性药物中的应用。本发明通过实验发现了PAP介导的RNA多聚腺苷酸化在脂肪代谢稳态的作用,Star‑PAP作为InsrRNA结合蛋白,其缺乏可以导致脂肪萎缩症和胰岛素抵抗,为下一步制备提高脂肪胰岛素敏感性药物奠定了基础。 专利权项:1.Star-PAP在制备提高脂肪胰岛素敏感性药...
Star-PAPpolyadenylationcell growth and proliferationCervical cancer is the most common genital malignancy and the high-risk human papillomaviruses (HPV type 16, 18 and 31, and so on) are major agents for its cause. A key switch for the onset of cervical cancers by HPVs is the cellular ...
Company Name Starpap Business Category Paper Recycling Address , ul. Rogowskiego 15StarachowiceSwietokrzyskiePolandZIP: 27-200 President NA Year Established 1996 Employees NA Memberships NA Hours of Operation NA CONTACT DETAILS KEY CONTACTS SHAREHOLDERS SUBSIDIARIES Phone Number Locked content Subscribe to...
Poly(A) polymerase (PAP) Canonical PAP PAP isoforms PAPα Star-PAP PI4,5P2 PIPKIα CKI Polyadenylation Uridylation 3′-end processing Oxidative stress 1. Introduction In eukaryotes, nuclear mRNA synthesis is a multistep process that begins with transcription and ends with processing at the 3′-...
nuclearPAPs,Star-PAPandPAPαwithageneraloverviewofPAPdiversityinthecell.Emerging evidencesuggestsdistinctnichesoftargetpre-mRNAsforthetwoPAPsandthatmodulationof thesePAPsregulatesdistinctcellularfunctions. Keywords Poly(A)polymerase(PAP);CanonicalPAP;PAPisoforms;PAPα;Star-PAP;PI4,5P 2 ;PIPKIα; CKI;Polyadeny...
from HEK 293 cells after Star-PAP or PIPKIα knockdown. − siRNA indicates that control scrambled siRNA was used. (E) Schematics of 3′-RACE (bottom) and cleavage (top) assays. CS, cleavage site. (F and H) Measurement of uncleaved pre-mRNA levels (F) expressed relative to total mRNA...
Star-PAP is a recently identified nuclear speckle localized non-canonical poly(A) polymerase that has a functional interaction with PIPKIα, and whose activity is modulated by the PIPKIα product, PI4,5P 2. Similar to other poly(A) polym... DL Mellman,RA Anderson - PubMed 被引量: 30发表...
Here, we employ HITS-CLIP to map the cellular Star-PAP binding landscape and the mechanism of global Star-PAP mRNA association. We show a transcriptome-wide association of Star-PAP that is diminished on Star-PAP depletion. Consistent with its role in the 3′-UTR processing, we observed a ...
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