Early stage of multiple sclerosisPrognostic markers in early MSPurpose of review: Multiple sclerosis (MS) is a demyelinating disease of the central nervous system that mainly affects young adults and that is one of the leading causes of disability in this age group, with cognitive impairment ...
Peripheral blood mononuclear cells (PBMCs) bear specific dysregulations in genes and pathways at distinct stages of multiple sclerosis (MS) that may help with classifying MS and non-MS subjects, specifying the early stage of disease, or discriminating among MS courses. Here we describe an unbiased...
The use of non-routine MRI sequences such as DIR has highlighted the role of gray matter (GM) pathology in multiple sclerosis (MS). The aim of this study was to assess the detection and relevance of cortical lesions (CLs) using MRI in early (<5 years) MS patients. 3D DIR and 3D FL...
The majority of these observed results were confirmed by significant interactions (P≤0.01) using continuous variables. The association between structural brain damage and functional cognitive impairment is substantially weaker in multiple sclerosis patients with a low disease burden. Therefore, disease ...
Retinal vessel density could represent a novel early biomarker to monitor the MS pathological burden. Keywords: OCTA; vessel density; initial demyelinating event; multiple sclerosis; prospective study1. Introduction Multiple sclerosis (MS) is an inflammatory, demyelinating disorder of the central nervous ...
Multiple sclerosis affects 2.5 million people worldwide, including 400,000 Americans. Get in-depth multiple sclerosis information here on symptoms and treatments of MS.
Some cases of multiple sclerosis (MS) or amyotrophic lateral sclerosis (ALS) Multiple-system atrophy, a group of degenerative brain diseases that affect speech, movement, and autonomic function Infections such as late-stage syphilis Although all types of dementia are progressive, the term progressive...
Human herpesvirus 6 infects the central nervous system of multiple sclerosis patients in the early stages of the disease The presence and the replicative state of human herpesvirus 6 (HHV-6) were evaluated in clinical samples from multiple sclerosis (MS) patients at the first... A Rotola,I ...
Acute monosymptomatic optic neuritis (AMON) may be the first indication of multiple sclerosis (MS), and this sign offers a special opportunity to study the... JL Frederiksen,HBW Larsson,J Olesen - 《Acta Neurologica Scandinavica》 被引量: 130发表: 1992年 The early phase of psoriatic arthritis...
This supports the notion of MS as a “2-stage” disease. Although conventional magnetic resonance imaging (cMRI) is characterized by a high sensitivity for detecting the presence of multiple sclerosis (MS) lesions, the magnitude of the correlation between the severity of disability and the extent...