Drug discovery is the process of identifying compounds that have the potential to become useful new therapies. Development of new drug involves two phases namely drug discovery and drug development. Internationally, India became a member of world trade organization (WTO) in 1995 & agreed to adhere...
Invasive ductal carcinoma (IDC) is the most common form of breast cancer which accounts for 85% of all breast cancer diagnoses. Non-invasive and early stages have a better prognosis than late-stage invasive cancer that has spread to lymph nodes. The invo
A false discovery rate of <0.1% was calculated using protein identifications validated using the Scaffold program (v.4.2.1). Proteins were classified according to GO categories using the program Blast2Go (31) and Pfam using HMMER v3.1b1 (32) and CD-domain, putative signal peptides and ...
Drug/compound%Inhibition Chloroquine 100 ± 1.78 8-Hydroxyquinoline 6± 0.42 UCF 501 0± 0.07 3.4. Stage specificity of UCF 501 growth inhibition Next, we defined the developmental stage specific action of UCF 501 by both microscopy and flow cytometry. Precise delineation of the timing of action...
There is no effective vaccine in use, and attempts to control the disease with drugs alone have been plagued by the development of drug-resistant parasites.2 Parasites initiate asymptomatic infection in the liver, when mosquito-transmitted sporozoites invade hepatocytes. Ensconced within their host ...
visualization and pathway enrichment analysis for gene expression studies Clara W. T. Koh 1, Justin S. G. Ooi 1, Eugenia Ziying Ong 2 & Kuan Rong Chan 1* Gene expression profiling has helped tremendously in the understanding of biological processes and ...
S. molnari blood stages (SMBS) are prime targets for parasite intervention therapy, as they are 1) responsible for massive proliferation in the earliest stages of infection of fish, 2) freely circulating in the blood and any drug targeting the SMBS would not need to be applied to host ...
Inflammation, Dermatitis, and Cosmetics CONTENTS Overview Definitions: inflammation and dermatitis Stages in the development of skin inflammation Causes and types of skin inflammation Contact dermatitis Types of contact dermatitis Hypoallergenic preparations Diagnosis* Principles of treatment Book: Chapter 14 ...
Compelling experimental evidence suggests that microglial activation is involved in the spread of tau tangles over the neocortex in Alzheimer’s disease (AD). We tested the hypothesis that the spatial propagation of microglial activation and tau accumulation colocalize in a Braak-like pattern in the ...
KEGG_Drug metabolism cytochrome P450 –1.93 2.2 KEGG_Tryptophan metabolisma –2.15 2.9 DKD, diabetic kidney disease; FDR, false discovery rate; GSEA, gene set enrichment analysis; KEGG, Kyoto Encyclopdia of Genes and Genomes; NES, normalized enrichment score; RIG-I, retinoic acid inducible gene ...