Methods:We retrospectively analyzed a wide range of CHB patients at different stages. The predictive power of serum complement component 3 (C3) levels for the development of acute-on-chronic liver failure (ACLF) in patients with decompensated cirrhosis was established and validated. Results:The ...
Blockage of the bile duct, which carries digestive enzymes from your liver into your intestines Certain inherited digestive disorders Some infections, including syphilis and brucellosis Bad reactions to certain medications Chronic heart failure with liver congestion ...
1,2 Portal hypertension (PH) represents a key driver of decompensation and mortality in ACLD patients.3 Moreover, patients with ACLD are at risk of developing acute-on-chronic liver failure (ACLF), a systemic inflammatory syndrome associated with multi-organ dysfunction.4,5 Considering the ...
Heart failure (HF) is a major public health problem characterized by inability of the heart to maintain sufficient output of blood. The systematic characterization of circulating proteins across different stages of HF may provide pathophysiological insig
Chronic kidney disease (CKD) is characterized by accumulation of protein-bound uremic toxins such as p-cresyl sulfate, p-cresyl glucuronide, indoxyl sulfate and indole-3-acetic acid, which originate in the gut. Intestinal bacteria metabolize aromatic amino acids into p-cresol and indole, (further...
Some examples of different "encephalopathy treatments" for different causes: Short-term anoxia (usually less than two minutes): Oxygen therapy Long-term anoxia: Rehabilitation Short-term alcohol toxicity: IV fluids or no therapy Long-term alcohol abuse (cirrhosis or chronic liver failure): Oral lact...
Chronic liver diseases usually developed through stepwise pathological transitions under the persistent risk factors. The molecular changes during liver transitions are pivotal to improve liver diagnostics and therapeutics yet still remain elusive. Cumulative large-scale liver transcriptomic studies have been re...
However, the long-term use of these medications is associated with a number of adverse kidney outcomes, including acute and chronic kidney injury, CKD development and progression, kidney failure, and both CKD-related and all-cause death.37 One study found that PPI use was associated with a 24...
Spread to the liver may be first identified by abnormal blood tests of liver function long before the patient has jaundice, a swollen liver, or any other signs of liver failure. Spread to the kidneys may cause pain and blood in the urine. Spread to the lungs may cause shortness of breath...
The 20-year-old male eagle received a biannual checkup in early October at the College of Veterinary Medicine followed by another echocardiogram Oct. 31. In 2017 he was diagnosed with cardiomyopathy, a chronic disease of the heart, and was sidelined from flying at football games to reduce...