The current standard of care for CLL Binet stage A patients is still the "watch and wait" strategy. Recently, 2 RCTs evaluating an immunochemotherapy by FCR (Herling 2020) or Ibrutinib (Langerbeins 2022) have failed to improve the prognosis of early-stage CLL patients. By contrast to ...
A study of the prognosis of two series of chronic lymphocytic leukemia (CLL) patients (99 from a retrospective series and 196 from a prospective series) has led us to propose a three-stage classification (A, B, C), requiring only a clinical examination and a haemogram. For stage A patien...
We report a randomized prospective phase 3 study (CLL7), designed to evaluate the efficacy of fludarabine, cyclophosphamide, and rituximab (FCR) in patients with an early-stage high-risk chronic lymphocytic leukemia (CLL). Eight hundred patients with untreated-stage Binet A disease were enrolled ...
B-cell chronic lymphocytic leukemia (B-CLL) is a clonal lymphoproliferative disorder with a highly variable clinical course and prognosis, which is associated with immune dysregulation, especially in the progressive phase. The leukemic clone may be regulated by inhibitory or growth-promoting signals by...
Vandenbergh E, Van de Woestijne KP, Gyselen A. Weight changes in the terminal stages of chronic obstructive pulmonary disease. Relation to respiratory function and prognosis. Amer Rev of Resp Dis. 1967;95(4):556-66. •• Collins PF, Stratton Rebecca J, Marinos E. Nutritional support ...
Amplification of the long arm of chromosome 8 is one of the most recurrent findings in prostate cancer and it is associated with poor prognosis. Several mi... Sanni,E.,Jalava,... - 《International Journal of Cancer》 被引量: 66发表: 2009年 加载更多研究...
In addition, we have compiled a list of microRNAs that are expressed differently in patients with metastatic melanoma compared with patients with non-metastatic melanoma and/or those whose up-or down-regulation correlates with a poor prognosis of the disease (Table 2). ...
More importantly, evaluation of LINC00885 expression levels in primary breast cancer samples could be useful as a biomarker of patient prognosis and outcome. Int. J. Mol. Sci. 2020, 21, 7407 Int. J. Mol. Sci. 2020, 21, x FOR PEER REVIEW 4 of 15 4 of 14 Figure 11.. LINC0000888855...
It is important to carefully evaluate neurological status in these patients and consider this entity between the differential diagnosis of a neurological deterioration as adequate treatment improves the prognosis. Imaging techniques, analyses of cerebrospinal fluid, and brain biopsy are useful to establish ...
Prognosis Assessment of Early-Stage Chronic Lymphocytic Leukemia: Are We Ready to Predict Clinical Evolution Without a Crystal Ball?Barcelona-BrnoCLL-01CLL-IPIIPS-ATailored approachBackground The discovery of new biological variables with high prognostic impact, has been accompanied by the emergence of...