In CLL, the achievement of CR with MRD negativity has emerged as a major goal to improve the prognosis and to optimize the duration of the treatment. For stage A CLL patients, the objective of the treatment is to achieve a CR with undetectable MRD to possibly eradicate the disease. Based ...
The aim of the multicenter, prospective CLL1 trial was to explore a novel prognostic model (CLL1-PM) developed to identify risk groups, separating patients with favorable from others with dismal prognosis. A cohort of 539 clinically, biochemically, and genetically characterized Binet stage A ...
Discuss that PEA may be due to true EMD, the end stage of many severe cardiac conditions. Review the findings in true EMD. Stress that because of its very poor prognosis, a rapid search for treatable causes is the key strategy. Stress that only a few reversible causes exist, and they ...
Locoregional radiation therapy is appropriate for patients with Ann Arbor stage I small lymphocytic lymphoma (SLL; ie, CLL largely limited to lymph nodes) In patients with localized SLL (Ann Arbor stage I) that progresses after initial radiation therapy or patients with advanced disease (Ann Arbor...
NOTCH1在CLL患者中的突变情况及预后价值
MCL is a rare subtype of non-Hodgkin's lymphoma and is known as an aggressive lymphoma with a poor prognosis. The disease progresses rapidly and has a high recurrence rate even after treatment. The number of patients in Korea is estimated to be around 150 annually. ...
3 Age, clinical stage, TP53 alterations, β2 microglobulin, and mutations of the immunoglobulin heavy variable chain (IGHV) gene were identified as independent prognostic factors for overall survival in patients treated with chemoimmunotherapy. Research in context Evidence before this study We searched ...
the 22 diagnoses, 15 (or 68 percent) were detected through monitoring in the UR Medicine dermatology clinic associated with Wilmot, and two cases (9 percent) were found by CLL specialists. Eighty eight percent of the cases involved earlier-stage disease with a better prognosis, the study said...
This is of considerable interest as we had previously shown that consumption of n-3 decreased the activity of nuclear factor kappa B (NFκB) in isolated lymphocytes of patients with early stage CLL and would be expected to slow the progression of the disease [12]. Studies have shown that ...
Loss of heterozygosity at 13q14 and 13q21 in high grade, high stage prostate cancer. Prostate 2001; 49: 166–171. Google Scholar Bullrich F, Fujii H, Calin G, Mabuchi H, Negrini M, Pekarsky Y et al. Characterization of the 13q14 tumor suppressor locus in CLL: identification of ALT...