Y染色体性别决定区(sex-determining region on the Y chromosome,SRY)是存在于Y染色体短臂Yp11.3区带的结构基因,可以编码出一种DNA结合蛋白,促使原始性腺发育为睾丸。大量的研究表明,人类性别决定的过程是以SRY基因为主导的、多个基因...
Once activated, one of the genes on the Y chromosome known as the SRY gene has two functions: to inhibit certain features of the X chromosome and to impose through dominance the physiological traits that a male must have. 在Y染色体中的SRY基因一旦被活化,就会有以下两种功能抑制X染色体的某些特征...
Incomplete masculinisation of XX subjects carrying the SRY gene on an inactive X chromosome. J Med Genet 1999; 36: 452-456.Kusz K,Kotecki M,Wojda A,Szarras Czapnik-M,Latos Bielenska-A,Warenik Szymankiewicz-A,Ruszczynska Wolska-A,Jaruzelska J. Incomplete masculinisation of XX subjects ...
Key words:sex region of Y chromosome; gene; development 1 SRY基因的寻找历程[1～8] 时代在进步,科技在发展,人们对宇宙的了解越来越多。然而,我们对于地球上最具智慧的生命——人类却知之甚少。What make man a man?这个看似最基本、最简单的性别决定问题却使无数科学家困惑了很久,至今仍是一个没有完全揭...
(byg) mutation. Thebygmutation is an A to T transversion that introduces a premature stop codon in the gene encoding mitogen-activated protein kinase (Mapk) kinase kinaseMap3k4(also known asMekk4). On the C57BL/6J background, E11.5byg/byggonads show impaired growth and a dramatic ...
Sry (Sex-determining region, Y Chromosome) In the early 1950s, it was discovered that the presence or absence of a Y chromosome determined whether a mammal developed as a male or female, respectively. It was hypothesized that a gene on the Y chromosome determined male sex and the human gen...
M. Graves 1994 AnSR Y2related sequence on the Marsupial X chromosome : implications for the evolution of the mam2 malian testis2determining gene.Proc.Natl. Acad. Sci.USA91 : 1 9271 931. Giese , K. 35、, J. Cox and R. Grosschedl 1992 The HMGdomain of lymphoid enhancer factor 1 ...
SRY is specific for the Y chromosome, but many autosomal genes have been identified that possess a similar HMG box region; those with the most closely SRY-related box regions form a gene family now referred to as SOX genes. We have identified a sequence on the marsupial X chromosome that ...
Y 染色体上 95%是男性特异区域,里面含和男性有关的基因。SRY 基因(Sex-determining Region on Y Chromosome,SRY),雄性的性别决定基因,指 Y 染色体上具体决定生物雄性性别的基因片段。人的 SRY 基因位于Yp11.3,只含有一个外显子,没有内含子,转录单位长约 1.1kb,编码一个 204 氨基酸的蛋白质。本产品就是以探针...
Stevanovic M, Lovell-Badge R, Collignon J and Goodfellow PN (1993) SOX3 is an X-linked gene related to SRY. Human Mol Genet 2: 2013–2018 CAS Google Scholar Foster JW and Graves JAM (1994) An SRY-related sequence on the marsupial X chromosome: implications for the evolution of the...