WT Flag-SRY has a mean nuclear intensity ratio of 72 meaning it is predominantly nuclear. The missense variant, p.Met85Thr severely affected nuclear localisation where fluorescence signal was detected mainly in the cytoplasm. In contrast, p.Tyr198Cysfs∗18 SRY variant mostly localised in the ...
However, in this study, SRY gene transcripts were also detected in somatic cells of adult male and in tumor cells. Moreover, this mRNA possessed a longer additional untranslated exon. Although expression of the transcripts might not have any functional meaning in these cells, these new findings ...