In addition, a pseudogene of this gene has been found on chromosome 11. 基因名: SRSF2 别名: PR264,SC-35,SC35,SFRS2,SFRS2A,SRp30b 基因ID: 6427 Chromosome:(GRCh37) 17 Start: 74730197 End: 74733456 Strand: -1 药物: Ziv-阿柏西普 SRSF2 基因突变与药物 MUTATION SRSF2 基因突变 MUTATION...
Thirty-four patients (29%) had a mutation in at least one of the spliceosome genes (=Splice-mut), including 20 (17%), 11 (9%), 4 (3%) and 1 (1%) mutations in SRSF2 , U2AF1 , SF3B1 and ZRSR2 , respectively (Fig.1) . Median variant allele frequency (VAF) was 42%, 43% ...
gene mutation is detected ~equenfl y in myeloid malignancies ( 1ike MDS and CMML ) and may be associated with the phenotype and prognosis of these mal i gn anci es.T he paper mak es a review for the l atest research progression on SRS F 2 gene mutati on and its relationship with ...
理杂志 ChineseJournalofPathophysiolo~ 2Ql4,0(1j; · 2289 · [文章编号] 1000—4718(2014)12-2289-05 SRSF2基因突变与髓系肿瘤 术 苗宁宁, 孟凡凯, 曾雯, 秦爽, 罗丹, 孙汉英 (华中科技大学同济医学院同济医院血液内科 ,湖北 武汉430030) SRSF2genemutationandmyeloidmalignancies MIAONing-ning,MENGFan—kai...
1P95Hand1P95Rpointmutations.Therewerenosignificantlystatisticaldifferencesintermsoftheirclinicalcharacteristicsbe-tweenmutantandwildtypegroup.ConclusionSRSF2mutationwasnotfrequentlyoccurredinCMMLpatientsandmightassociatedwithpoorprognosis.Itmightbeapraticallydiagnosticmakerandtherapeu-tictargetinCMML.【Keywords】Gene,SRSF2...
急性髓系白血病SRSF2基因突变患者临床病理特征及预后生存分析
SRSF2 mutations could directly affect pre-mRNA splicing of a vital gene product; alternatively, a whole network of gene products could be affected. Here we determine how SRSF2 mutations globally affect RNA binding and splicing in vivo using HITS-CLIP. Remarkably, the majority of differential ...
Objective: To investigate the gene mutation and the clinical features of CSF3R, SETBP1 and SRSF2 in chronic neutrophilic leukemia (CNL) and chronic myelomonocytic leukemia (CMML) patients. Method: Sequence analysis of CSF3R, SETBP1 and SRSF2 were performed in 10 CNL and 56 CMML patients whose...
The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS ...
OPEN Letters to the Editor 253 SRSF2 and U2AF1 mutations in primary myelofibrosis are associated with JAK2 and MPL but not calreticulin mutation and may independently reoccur after allogeneic stem cell transplantation Leukemia (2015) 29, 253–255; doi:10.1038/leu.2014.277 Spliceosome gene mutations ...