In the liver, ZDHHC16-mediated PCSK9 palmitoylation promotes cell proliferation by activating PI3K/AkT pathway74. In this study, we found that expression of ZDHHC23 is significantly correlated with poor survival of HCC patients. In contrast, palmitoylation could suppress tumor growth. For example, ...
然而,PCSK9促进AS形成的具体机制并不清楚,且关于PCSK9对荷脂细胞胆固醇流出的影响的研究国内外罕见报道.目的:研究PCSK9对THP-1源性荷脂细胞胆固醇流出的影响,并初步探讨类固醇调节因子结合蛋白-2(SREBP-2)蛋白表达在其中的作用.方法:1.建立荷脂细胞模型 体外培养人单核细胞(THP-1)系细胞,用100ng/ml佛波脂(PMA...
Gain-of-function mutations within proprotein convertase subtilisin kexin type 9 (PCSK9) are linked to familial autosomal dominant hypercholesterolaemia, a disease characterized by elevated plasma concentrations of cholesterol associated with low-density lipoproteins (LDLs). Conversely, PCSK9 loss-of-...
19]. The N-terminal region of SCAP functions as a sterol-sensing domain. At high cellular sterol levels, SCAP binds cholesterol, undergoes a conformational
In circulatory system, inhibiting the transcriptional activation of SREBP2 leads to a decrease in PCSK9, consequently enhancing the LDLR expression and LDLc clearance [99]. Controlling the balance of cholesterol also regulates the process of erythroid differentiation. By binding to GATA1, SREBP2 ...
PCSK9 is a natural inhibitor of LDL receptor (LDLR) that binds the extracellular domain of LDLR and triggers its intracellular degradation. PCSK9 and LDLR are coordinately regulated at the transcriptional level by sterols through their p... L Hai,B Dong,SW Park,... - 《Journal of Biological...
Strong induction of PCSK9 gene expression through HNF1α and SREBP2: mechanism for the resistance to LDL-cholesterol lowering effect of statins in dyslipid... We investigated the role of proprotein convertase subtilisin/kexin type 9 (PCSK9) in the resistance of dyslipidemic hamsters to statin-ind...
A case of hypocholesterolemia and steatosis in a carrier of a PCSK9 loss-of-function mutation and polymorphisms predisposing to nonalcoholic fatty liver disease J. Clin. Lipidol., 11 (2017), pp. 1101-1105 View PDFView articleView in ScopusGoogle Scholar 26 E. Smagris, S. Gilyard, S. ...
Three such genes include Pcsk9 [58], Stard4 [59], and LDL receptor [60]; each is linked to cholesterol trafficking. The Cyp1b1−/− mice that result from prolonged maintenance and breeding practices involving the BD diet fail to suppress diet-induced obesity (DIO), i.e., they ...
Effects of rosuvastatin on gene expression of liver LDL-R, Pcsk9, SREBP-2, and Lrp1 in ovariectomized rats submitted or not to voluntary exerciseStudies on normoglycemic ovariectomized Sprague-Dawley rats have provided insights about the effects of estrogen deficiency on insulin resistance in lean ...